How CRISPR technology is advancing

Fewer off-target edits and greater targeting scope bring gene editing technology closer to treating human diseases.

Caitlin McDermott-Murphy | Feb. 14, 2020 | harvard
~7 mins   

Tags: science-technology base-editing base-editors biotechnology-nature broad-institute caitlin-mcdermott-murphy cas9 chemistry chemistry-and-chemical-biology crispr david-liu dna gene-editing genetic-disease genetic-engineering genome rna sickle-cell-anemia

The story behind the mumps outbreaks of 2016-17

Studying the mumps virus genomes in 2016 and 2017 filled in gaps about how the disease was spreading in Massachusetts and elsewhere in the U.S.

Karen Zusi | Feb. 11, 2020 | harvard
~8 mins   

Tags: science-technology basic-research broad-institute-of-mit-and-harvard engineering pardis-sabeti plos-biology viral-genomics

Big step toward identifying all cancer-causing genetic mutations

An international team of 1,300 scientists has generated the most complete cancer genome map to date, bringing researchers closer to identifying all major cancer-causing genetic mutations.

Stephanie McPherson | Feb. 5, 2020 | harvard
~12 mins   

Tags: science-technology basic-research bioengineering broad-institute-of-mit-and-harvard cancer-genome-map cancer-causing-genetic-mutations engineering icgctcga-pan-cancer-analysis-of-whole-genomes-project pan-cancer-project whole-cancer-genomes

Preventing sudden cardiac death through gene sequencing

Researchers have determined that genetic testing could identify those at risk for cardiac death prior to any symptoms.

Harvard Gazette | Nov. 16, 2019 | harvard
~4 mins   

Tags: science-technology basic-research broad-institute-of-mit-and-harvard cardiac-death gene-sequencing

New blood test could be used to help millions infected with TB

A team of researchers has developed a point-of-care TB test that costs only $2 and gives results in about 30 minutes, lowering the barrier to care in low-resource settings and potentially saving millions of lives.

Lindsay Brownell | Oct. 23, 2019 | harvard
~9 mins   

Tags: health-medicine active-tuberculosis atb brigham-and-womens-hospital broad-institute-of-harvard-and-mit tb tb-triage-test wyss-institute-for-biologically-inspired-engineering

Researchers can program a CRISPR enzyme to kill viruses in human cells

Researchers have turned a CRISPR enzyme into an antiviral that can be programmed to detect and destroy RNA-based viruses in human cells.

Karen Zusi | Oct. 10, 2019 | harvard
~5 mins   

Tags: science-technology broad-institute-of-mit-and-harvard carver cas13-enzyme cas13-assisted-restriction-of-viral-expression-and-readout crispr ebola flu rna rna-based-viruses sherlock virus zika

Brigham, Broad Institute researchers ID molecules that rein in CRISPR systems

Scientists have identified the first chemical compounds able to inhibit and regulate CRISPR systems, which could ultimately make CRISPR gene-editing technologies more precise, efficient, and safe.

Karen Zusi | May 2, 2019 | harvard
~5 mins   

Tags: science-technology amit-choudhary brigham-and-womens-hospital broad-institute cas-enzymes cell crispr gene-editing

New tool calculates genetic risk for obesity

A “polygenic score” for obesity, a quantitative tool that predicts an individual’s inherited risk for becoming overweight, may identify an opportunity for early intervention.

Karen Zusi | April 18, 2019 | harvard
~6 mins   

Tags: health-medicine amit-v-khera avon-longitudinal-study-of-parents-and-children broad-institute clinical-interventions coronary-artery-risk-development-in-young-adults-study dna framingham-offspring-study genetic obesity polygenic-score polygenic-scoring uk-biobank

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