How CRISPR technology is advancing

Fewer off-target edits and greater targeting scope bring gene editing technology closer to treating human diseases.

Caitlin McDermott-Murphy | Feb. 14, 2020 | harvard
~7 mins   

Tags: science-technology base-editing base-editors biotechnology-nature broad-institute caitlin-mcdermott-murphy cas9 chemistry chemistry-and-chemical-biology crispr david-liu dna gene-editing genetic-disease genetic-engineering genome rna sickle-cell-anemia

Radcliffe symposium examines rapid advances brought by CRISPR

CRISPR gene-editing technology has conquered the lab and is poised to lead to new treatments for human disease. Experts consider the promise and peril at Radcliffe.

Alvin Powell | Oct. 28, 2019 | harvard
~7 mins   

Tags: science-technology alvin-powell crispr gene-editing gene-therapy immaculata-de-vivo jonathan-kimmelman kiran-musunuru radcliffe-institute-for-advanced-study sylvain-moineau vence-bonham

Researchers can program a CRISPR enzyme to kill viruses in human cells

Researchers have turned a CRISPR enzyme into an antiviral that can be programmed to detect and destroy RNA-based viruses in human cells.

Karen Zusi | Oct. 10, 2019 | harvard
~5 mins   

Tags: science-technology broad-institute-of-mit-and-harvard carver cas13-enzyme cas13-assisted-restriction-of-viral-expression-and-readout crispr ebola flu rna rna-based-viruses sherlock virus zika

New 3D mini brain models accelerate neuroscience research

Research led by scientists at Harvard and the Broad Institute has optimized the process of making human brain “organoids” — miniature 3D organ models — so they consistently follow growth patterns observed in the developing human brain.

Harvard Gazette | June 5, 2019 | harvard
~8 mins   

Tags: science-technology aviv-regev basic-research brain broad-insitute crispr doug-melton neuroscience organoids paola-arlotta reproducibility silvia-velasco single-cell-sequencing steven-hyman yoshiki-sasai

Broad Institute researchers develop 3D mini brain models

Research led by scientists at Harvard and the Broad Institute has optimized the process of making human brain “organoids” — miniature 3D organ models — so they consistently follow growth patterns observed in the developing human brain.

Harvard Gazette | June 5, 2019 | harvard
~8 mins   

Tags: science-technology aviv-regev basic-research brain crispr doug-melton neuroscience organic paola-arlotta reproducibility silvia-velasco single-cell-sequencing steven-hyman yoshiki-sasai

Harvard chemist teases out why drugs work (or don’t)

Assistant Professor Brian Liau of the Chemistry and Chemical Biology Department has answered the question of why some new drugs for acute myeloid leukemia don’t work by combining CRISPR gene editing with small-molecule inhibitor treatments in a technique he calls CRISPR-suppressor scanning.

Caitlin McDermott-Murphy | May 6, 2019 | harvard
~7 mins   

Tags: science-technology acute-myeloid-leukemia aml brian-liau chemistry chemistry-and-chemical-biology crispr leukemia nature-chemical-biology

Brigham, Broad Institute researchers ID molecules that rein in CRISPR systems

Scientists have identified the first chemical compounds able to inhibit and regulate CRISPR systems, which could ultimately make CRISPR gene-editing technologies more precise, efficient, and safe.

Karen Zusi | May 2, 2019 | harvard
~5 mins   

Tags: science-technology amit-choudhary brigham-and-womens-hospital broad-institute cas-enzymes cell crispr gene-editing

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