Removing the constraining requirements at gene editing site

Investigators at Massachusetts General Hospital have modified the gene editing system, making it possible to potentially target any location across the entire human genome.

Harvard Gazette • harvard
March 26, 2020 ~3 min

Tags:  science-technology  crispr  cancer  basic-research  mgh  blindness  gene-editing  benjamin-p-kleinstiver  cas9  center-for-genomic-medicine

How CRISPR technology is advancing

Fewer off-target edits and greater targeting scope bring gene editing technology closer to treating human diseases.

Caitlin McDermott-Murphy • harvard
Feb. 14, 2020 ~7 min

Tags:  science-technology  dna  chemistry  crispr  genome  chemistry-and-chemical-biology  rna  gene-editing  broad-institute  caitlin-mcdermott-murphy  cas9  base-editing  base-editors  biotechnology-nature  david-liu  genetic-disease  genetic-engineering  sickle-cell-anemia

Radcliffe symposium examines rapid advances brought by CRISPR

CRISPR gene-editing technology has conquered the lab and is poised to lead to new treatments for human disease. Experts consider the promise and peril at Radcliffe.

Alvin Powell • harvard
Oct. 28, 2019 ~7 min

Tags:  science-technology  crispr  radcliffe-institute-for-advanced-study  alvin-powell  gene-therapy  gene-editing  immaculata-de-vivo  jonathan-kimmelman  kiran-musunuru  sylvain-moineau  vence-bonham

Researchers can program a CRISPR enzyme to kill viruses in human cells

Researchers have turned a CRISPR enzyme into an antiviral that can be programmed to detect and destroy RNA-based viruses in human cells.

Karen Zusi • harvard
Oct. 10, 2019 ~5 min

Tags:  science-technology  crispr  ebola  rna  virus  broad-institute-of-mit-and-harvard  carver  cas13-enzyme  cas13-assisted-restriction-of-viral-expression-and-readout  flu  rna-based-viruses  sherlock  zika

New 3D mini brain models accelerate neuroscience research

Research led by scientists at Harvard and the Broad Institute has optimized the process of making human brain “organoids” — miniature 3D organ models — so they consistently follow growth patterns observed in the developing human brain.

Harvard Gazette • harvard
June 5, 2019 ~8 min

Tags:  science-technology  crispr  brain  neuroscience  basic-research  organoids  paola-arlotta  aviv-regev  broad-insitute  doug-melton  reproducibility  silvia-velasco  single-cell-sequencing  steven-hyman  yoshiki-sasai

Broad Institute researchers develop 3D mini brain models

Research led by scientists at Harvard and the Broad Institute has optimized the process of making human brain “organoids” — miniature 3D organ models — so they consistently follow growth patterns observed in the developing human brain.

Harvard Gazette • harvard
June 5, 2019 ~8 min

Tags:  science-technology  crispr  brain  neuroscience  basic-research  paola-arlotta  aviv-regev  doug-melton  reproducibility  silvia-velasco  single-cell-sequencing  steven-hyman  yoshiki-sasai  organic

Harvard chemist teases out why drugs work (or don’t)

Assistant Professor Brian Liau of the Chemistry and Chemical Biology Department has answered the question of why some new drugs for acute myeloid leukemia don’t work by combining CRISPR gene editing with small-molecule inhibitor treatments in a technique he calls CRISPR-suppressor scanning.

Caitlin McDermott-Murphy • harvard
May 6, 2019 ~7 min

Tags:  science-technology  chemistry  crispr  chemistry-and-chemical-biology  acute-myeloid-leukemia  aml  brian-liau  leukemia  nature-chemical-biology

Brigham, Broad Institute researchers ID molecules that rein in CRISPR systems

Scientists have identified the first chemical compounds able to inhibit and regulate CRISPR systems, which could ultimately make CRISPR gene-editing technologies more precise, efficient, and safe.

Karen Zusi • harvard
May 2, 2019 ~5 min

Tags:  science-technology  crispr  cell  brigham-and-womens-hospital  gene-editing  amit-choudhary  broad-institute  cas-enzymes

Page 1 of 1