Gene editing may be a path to restore partial hearing
Wei Hsi “Ariel” Yeh dedicated her research in chemistry to solving some of the vast genetic mysteries behind hearing loss.
June 5, 2020 • ~6 min
science-technology dna chemistry crispr genome basic-research howard-hughes-medical-institute chemistry-and-chemical-biology rna gene-editing broad-institute caitlin-mcdermott-murphy deafness hearing-loss cas9 base-editing base-editors david-liu genetic-disease genetic-engineering sickle-cell-anemia progeria tmc1
Removing the constraining requirements at gene editing site
Investigators at Massachusetts General Hospital have modified the gene editing system, making it possible to potentially target any location across the entire human genome.
March 26, 2020 • ~3 min
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How CRISPR technology is advancing
Fewer off-target edits and greater targeting scope bring gene editing technology closer to treating human diseases.
Feb. 14, 2020 • ~7 min
science-technology dna chemistry crispr genome chemistry-and-chemical-biology rna gene-editing broad-institute caitlin-mcdermott-murphy cas9 base-editing base-editors biotechnology-nature david-liu genetic-disease genetic-engineering sickle-cell-anemia
Radcliffe symposium examines rapid advances brought by CRISPR
CRISPR gene-editing technology has conquered the lab and is poised to lead to new treatments for human disease. Experts consider the promise and peril at Radcliffe.
Oct. 28, 2019 • ~7 min
science-technology crispr radcliffe-institute-for-advanced-study alvin-powell gene-therapy gene-editing immaculata-de-vivo jonathan-kimmelman kiran-musunuru sylvain-moineau vence-bonham
Researchers can program a CRISPR enzyme to kill viruses in human cells
Researchers have turned a CRISPR enzyme into an antiviral that can be programmed to detect and destroy RNA-based viruses in human cells.
Oct. 10, 2019 • ~5 min
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New 3D mini brain models accelerate neuroscience research
Research led by scientists at Harvard and the Broad Institute has optimized the process of making human brain “organoids” — miniature 3D organ models — so they consistently follow growth patterns observed in the developing human brain.
June 5, 2019 • ~8 min
science-technology crispr brain neuroscience basic-research organoids paola-arlotta aviv-regev broad-insitute doug-melton reproducibility silvia-velasco single-cell-sequencing steven-hyman yoshiki-sasai
Broad Institute researchers develop 3D mini brain models
Research led by scientists at Harvard and the Broad Institute has optimized the process of making human brain “organoids” — miniature 3D organ models — so they consistently follow growth patterns observed in the developing human brain.
June 5, 2019 • ~8 min
science-technology crispr brain neuroscience basic-research paola-arlotta aviv-regev doug-melton reproducibility silvia-velasco single-cell-sequencing steven-hyman yoshiki-sasai organic
Harvard chemist teases out why drugs work (or don’t)
Assistant Professor Brian Liau of the Chemistry and Chemical Biology Department has answered the question of why some new drugs for acute myeloid leukemia don’t work by combining CRISPR gene editing with small-molecule inhibitor treatments in a technique he calls CRISPR-suppressor scanning.
May 6, 2019 • ~7 min
science-technology chemistry crispr chemistry-and-chemical-biology acute-myeloid-leukemia aml brian-liau leukemia nature-chemical-biology
Brigham, Broad Institute researchers ID molecules that rein in CRISPR systems
Scientists have identified the first chemical compounds able to inhibit and regulate CRISPR systems, which could ultimately make CRISPR gene-editing technologies more precise, efficient, and safe.
May 2, 2019 • ~5 min
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