Analyzing toehold sequences for synthetic biology

Computational algorithms enable identification and optimization of RNA-based tools for myriad applications.

Lindsay Brownell • harvard
Oct. 7, 2020 ~16 min

Tags: science-technology dna synthetic-biology rna wyss-institute james-collins


How CRISPR technology is advancing

Fewer off-target edits and greater targeting scope bring gene editing technology closer to treating human diseases.

Caitlin McDermott-Murphy • harvard
Feb. 14, 2020 ~7 min

Tags:  science-technology  dna  chemistry  crispr  genome  chemistry-and-chemical-biology  rna  gene-editing  broad-institute  caitlin-mcdermott-murphy  cas9  base-editing  base-editors  biotechnology-nature  david-liu  genetic-disease  genetic-engineering  sickle-cell-anemia

Study likens Earth’s evolution to creation of Frankenstein’s monster

The evolution of the first building blocks on Earth may have been messier than previously thought, likening it to the mishmash creation of Frankenstein’s monster.

Caitlin McDermott-Murphy • harvard
Jan. 28, 2020 ~4 min

Tags:  science-technology  engineering  dna  chemistry  genetics  basic-research  chemistry-and-chemical-biology  jack-szostak  origins-of-life  rna  science  caitlin-mcdermott-murphy  primordial-soup  prebiotic  seohyun-kim

Researchers can program a CRISPR enzyme to kill viruses in human cells

Researchers have turned a CRISPR enzyme into an antiviral that can be programmed to detect and destroy RNA-based viruses in human cells.

Karen Zusi • harvard
Oct. 10, 2019 ~5 min

Tags:  science-technology  crispr  ebola  rna  virus  broad-institute-of-mit-and-harvard  carver  cas13-enzyme  cas13-assisted-restriction-of-viral-expression-and-readout  flu  rna-based-viruses  sherlock  zika

Inosine could be a potential route to the first RNA, Harvard study says

In a paper published in PNAS, Jack W. Szostak, professor of chemistry and chemical biology at Harvard, along with graduate student Seohyun (Chris) Kim, suggest that RNA could have started with a different set of nucleotide bases. In place of guanine, RNA could have relied on a surrogate, inosine.

Caitlin McDermott-Murphy • harvard
Dec. 10, 2018 ~4 min

Tags:  science-technology  faculty-of-arts-and-sciences  fas  harvard  chemistry-and-chemical-biology  inosine  jack-szostak  life  origins-of-life  rna  szostak

Inosine could be a potential route to the first RNA, Harvard study says

In a paper published in PNAS, Jack W. Szostak, professor of chemistry and chemical biology at Harvard, along with graduate student Seohyun (Chris) Kim, suggest that RNA could have started with a different set of nucleotide bases. In place of guanine, RNA could have relied on a surrogate, inosine.

Caitlin McDermott-Murphy • harvard
Dec. 10, 2018 ~4 min

Tags:  science-technology  faculty-of-arts-and-sciences  fas  harvard  chemistry-and-chemical-biology  inosine  jack-szostak  life  origins-of-life  rna  szostak

Page 1 of 1