In people carrying APOE4, a key brain cell mismanages cholesterol needed to insulate neurons properly — another sign APOE4 contributes to disease by disrupting brain lipids.

Study indicates ailing neurons may instigate an inflammatory response from the brain’s microglia immune cells.

Program supports family caregivers with dedicated service coordinators based on learning from MIT's AgeLab.

Targeting these circuits could offer a new way to reverse motor dysfunction and depression in Parkinson’s patients.

Two types of tau proteins mix together in a nearly random way to generate the tangles seen in the brains of Alzheimer’s patients.

K. Lisa Yang Brain-Body Center to investigate the brain’s complex relationship with other body systems.

This circuit, which weakens with age, could offer a target to help prevent age-related decline in spatial memory.

Extra chromosome alters chromosomal conformation and DNA accessibility in neural progenitor cells, disrupting gene transcription and cell functions much like in cellular aging.

MIT biologists show that enlargement of blood stem cells restricts their ability to generate new blood cells during aging.

The findings may help explain why some people who lead enriching lives are less prone to Alzheimer’s and age-related dementia.