Study shows fragile X treatment can incur resistance, suggests ways around it

While the brain acquires resistance to continuous treatment with mGluR5 inhibitor drugs, lasting effects may still arise if dosing occurs intermittently and during a developmental-critical period.

David Orenstein | Picower Institute for Learning and Memory • mit
Oct. 15, 2021 ~10 min

Some brain disorders exhibit similar circuit malfunctions

Study suggests a common mechanism underlies some behavioral traits seen in autism and schizophrenia.

Anne Trafton | MIT News Office • mit
June 30, 2021 ~7 min


Mapping the brain’s sensory gatekeeper

New analysis could help uncover potential drug targets for attention deficits and sensory hypersensitivity.

Anne Trafton | MIT News Office • mit
July 22, 2020 ~7 min

Findings weaken notion that size equals strength for neural connections

Among study’s many surprises may be a new way to address Fragile X syndrome — by finding a “protein X.”

David Orenstein | Picower Institute for Learning and Memory • mit
July 14, 2020 ~5 min

Scientists find a new way to reverse symptoms of Fragile X

Drug compound, tested in mice, could be effective in treating the leading heritable cause of intellectual disability and autism.

Anne Trafton | MIT News Office • mit
May 20, 2020 ~8 min

The neural basis of sensory hypersensitivity

A new study may explain why people with autism are often highly sensitive to light and noise.

Anne Trafton | MIT News Office • mit
March 2, 2020 ~6 min

Study may explain how infections reduce autism symptoms

An immune molecule sometimes produced during infection can influence the social behavior of mice.

Anne Trafton | MIT News Office • mit
Dec. 18, 2019 ~8 min

Drug combination reverses hypersensitivity to noise

Findings in mice suggest targeting certain brain circuits could offer new ways to treat some neurological disorders.

Anne Trafton | MIT News Office • mit
Oct. 21, 2019 ~7 min


Neuroscientists identify brain region linked to altered social interactions in autism model

In a mouse model, restoring activity of a specific forebrain region reverses social traits associated with autism.

Sabbi Lall | McGovern Institute for Brain Research • mit
July 26, 2019 ~4 min

Using gene editing, neuroscientists develop a new model for autism

By introducing a gene variant associated with autism into monkeys, researchers hope to study treatment options for severe neurodevelopmental disorders.

Anne Trafton | MIT News Office • mit
June 12, 2019 ~9 min

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