An “oracle” for predicting the evolution of gene regulation
Researchers create a mathematical framework to examine the genome and detect signatures of natural selection, deciphering the evolutionary past and future of non-coding DNA.
Raleigh McElvery | Department of Biology •
mit
March 11, 2022 • ~9 min
March 11, 2022 • ~9 min
In Down syndrome cells, genome-wide disruptions mimic a senescence-like state
Extra chromosome alters chromosomal conformation and DNA accessibility in neural progenitor cells, disrupting gene transcription and cell functions much like in cellular aging.
David Orenstein | Picower Institute •
mit
Jan. 10, 2022 • ~7 min
Jan. 10, 2022 • ~7 min
Differences in T cells’ functional states determine resistance to cancer therapy
Researchers decipher when and why immune cells fail to respond to immunotherapy, and suggest that T cells need a different kind of prodding in order to re-engage the immune response.
Grace van Deelen | Department of Biology •
mit
Nov. 1, 2021 • ~7 min
Nov. 1, 2021 • ~7 min
Research collaboration puts climate-resilient crops in sight
MIT professors Dave Des Marais and Caroline Uhler combine plant biology and machine learning to identify genetic roots of plant responses to environmental stress.
Alison Gold | Abdul Latif Jameel Water and Food Systems Lab •
mit
Sept. 17, 2021 • ~8 min
Sept. 17, 2021 • ~8 min
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