Without a key extracellular protein, neuronal axons break and synaptic connections fall apart

Scientists find a protein common to flies and people is essential for supporting the structure of axons that neurons project to make circuit connections.

David Orenstein | The Picower Institute for Learning and Memory • mit
June 23, 2023 ~7 min

Atlas of human brain blood vessels highlights changes in Alzheimer’s disease

MIT researchers characterize gene expression patterns for 22,500 brain vascular cells across 428 donors, revealing insights for Alzheimer’s onset and potential treatments.

Rachel Gordon | MIT CSAIL • mit
June 21, 2023 ~17 min


40 Hz vibrations reduce Alzheimer’s pathology, symptoms in mouse models

Tactile stimulation improved motor performance, reduced phosphorylated tau, preserved neurons and synapses, and reduced DNA damage, a new study shows.

David Orenstein | The Picower Institute for Learning and Memory • mit
June 5, 2023 ~7 min

3 Questions: A new model of nervous system form, function, and evolution

Developing a new neuroscience model is no small feat. New faculty member Brady Weissbourd has risen to the challenge in order to study nervous system evolution, development, regeneration, and function.

Lillian Eden | Department of Biology • mit
May 22, 2023 ~9 min

From molecular to whole-brain scale in a simple animal, study reveals serotonin’s effects

With full genetic control and visibility into neural activity and behavior, MIT scientists map out chemical’s role in behavior.

David Orenstein | Picower Institute for Learning and Memory • mit
May 22, 2023 ~7 min

Scientists discover how mutations in a language gene produce speech deficits

Faulty versions of the Foxp2 gene disrupt neurons’ ability to form synapses in brain regions involved in speech, a new study shows.

Anne Trafton | MIT News Office • mit
May 3, 2023 ~7 min

Scientists discover anatomical changes in the brains of the newly sighted

Following cataract removal, some of the brain’s visual pathways seem to be more malleable than previously thought.

Anne Trafton | MIT News Office • mit
May 1, 2023 ~8 min

3 Questions: Mriganka Sur on researching the first approved drug to treat Rett syndrome

On March 10 the FDA approved Trofinetide, a drug based on the protein IGF-1. The MIT professor's original research showing that IGF-1 could treat Rett was published in 2009.

David Orenstein | Picower Institute for Learning and Memory • mit
March 13, 2023 ~9 min


Studies of unusual brains reveal critical insights into brain organization, function

Ev Fedorenko’s Interesting Brains Project highlights the human brain’s remarkable capacity to adapt, reorganize in the face of early damage.

Thea Singer | McGovern Institute for Brain Research • mit
Feb. 21, 2023 ~10 min

Researchers map brain cell changes in Alzheimer’s disease

Study reveals key cell structures and gene expression changes near amyloid plaques and tau tangles in mouse brain tissue.

Allessandra DiCorato | Broad Institute • mit
Feb. 2, 2023 ~7 min

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