Without a key extracellular protein, neuronal axons break and synaptic connections fall apart

Scientists find a protein common to flies and people is essential for supporting the structure of axons that neurons project to make circuit connections.

David Orenstein | The Picower Institute for Learning and Memory • mit
June 23, 2023 ~7 min

Atlas of human brain blood vessels highlights changes in Alzheimer’s disease

MIT researchers characterize gene expression patterns for 22,500 brain vascular cells across 428 donors, revealing insights for Alzheimer’s onset and potential treatments.

Rachel Gordon | MIT CSAIL • mit
June 21, 2023 ~17 min


40 Hz vibrations reduce Alzheimer’s pathology, symptoms in mouse models

Tactile stimulation improved motor performance, reduced phosphorylated tau, preserved neurons and synapses, and reduced DNA damage, a new study shows.

David Orenstein | The Picower Institute for Learning and Memory • mit
June 5, 2023 ~7 min

3 Questions: A new model of nervous system form, function, and evolution

Developing a new neuroscience model is no small feat. New faculty member Brady Weissbourd has risen to the challenge in order to study nervous system evolution, development, regeneration, and function.

Lillian Eden | Department of Biology • mit
May 22, 2023 ~9 min

From molecular to whole-brain scale in a simple animal, study reveals serotonin’s effects

With full genetic control and visibility into neural activity and behavior, MIT scientists map out chemical’s role in behavior.

David Orenstein | Picower Institute for Learning and Memory • mit
May 22, 2023 ~7 min

3 Questions: Mriganka Sur on researching the first approved drug to treat Rett syndrome

On March 10 the FDA approved Trofinetide, a drug based on the protein IGF-1. The MIT professor's original research showing that IGF-1 could treat Rett was published in 2009.

David Orenstein | Picower Institute for Learning and Memory • mit
March 13, 2023 ~9 min

Sparse, small, but diverse neural connections help make perception reliable, efficient

First detailed mapping and modeling of thalamus inputs onto visual cortex neurons show brain leverages “wisdom of the crowd” to process sensory information.

David Orenstein | Picower Institute for Learning and Memory • mit
Feb. 2, 2023 ~9 min

New technologies reveal cross-cutting breakdowns in Alzheimer’s disease

“Single-cell profiling” is helping neuroscientists see how disease affects major brain cell types and identify common, potentially targetable pathways.

David Orenstein | Picower Institute for Learning and Memory • mit
Jan. 18, 2023 ~6 min


Holding information in mind may mean storing it among synapses

Comparing models of working memory with real-world data, MIT researchers find information resides not in persistent neural activity, but in the pattern of its connections.

David Orenstein | Picower Institute for Learning and Memory • mit
Jan. 12, 2023 ~8 min

Small studies of 40-hertz sensory stimulation confirm safety, suggest Alzheimer’s benefits

MIT researchers report early-stage clinical study results of tests with noninvasive 40-hertz light and sound treatment.

David Orenstein | Picower Institute for Learning and Memory • mit
Dec. 13, 2022 ~9 min

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