With AI, researchers predict the location of virtually any protein within a human cell

Trained with a joint understanding of protein and cell behavior, the model could help with diagnosing disease and developing new drugs.

Adam Zewe | MIT News • mit
May 15, 2025 ~8 min

A brief history of expansion microscopy

Since an MIT team introduced expansion microscopy in 2015, the technique has powered the science behind kidney disease, plant seeds, the microbiome, Alzheimer’s, viruses, and more.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
April 23, 2025 ~13 min


Study suggests new molecular strategy for treating fragile X syndrome

Enhancing activity of a specific component of neurons’ “NMDA” receptors normalized protein synthesis, neural activity, and seizure susceptibility in the hippocampus of fragile X lab mice.

David Orenstein | The Picower Institute for Learning and Memory • mit
March 4, 2025 ~7 min

Seeing more in expansion microscopy

New methods light up lipid membranes and let researchers see sets of proteins inside cells with high resolution.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
March 3, 2025 ~10 min

An ancient RNA-guided system could simplify delivery of gene editing therapies

The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
Feb. 27, 2025 ~7 min

AI system predicts protein fragments that can bind to or inhibit a target

FragFold, developed by MIT Biology researchers, is a computational method with potential for impact on biological research and therapeutic applications.

Lillian Eden | Department of Biology • mit
Feb. 20, 2025 ~9 min

AI model deciphers the code in proteins that tells them where to go

Whitehead Institute and CSAIL researchers created a machine-learning model to predict and generate protein localization, with implications for understanding and remedying disease.

Greta Friar | Whitehead Institute • mit
Feb. 13, 2025 ~11 min

MIT method enables ultrafast protein labeling of tens of millions of densely packed cells

Tissue processing advance can label proteins at the level of individual cells across large samples just as fast and uniformly as in dissociated single cells.

David Orenstein | The Picower Institute for Learning and Memory • mit
Feb. 6, 2025 ~9 min


Cellular traffic congestion in chronic diseases suggests new therapeutic targets

Chronic diseases like diabetes are prevalent, costly, and challenging to treat. A common denominator driving them may be a promising new therapeutic target.

Greta Friar | Whitehead Institute • mit
Dec. 10, 2024 ~10 min

CHARMed collaboration creates a potent therapy candidate for fatal prion diseases

A new gene-silencing tool shows promise as a future therapy against prion diseases and paves the way for new approaches to treating disease.

Greta Friar | Whitehead Institute • mit
June 27, 2024 ~12 min

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