IGPS_fitness_landscapes.png
Summary
Description IGPS fitness landscapes.png |
Experimentally derived fitness landscapes mapped from point mutations represent single steps from WT sequence. Despite significant divergence of WT in sequence space, the fitness landscapes of IGPS orthologues remain correlated (dashed lines). Rather than traditional two-dimensional heatmaps, fitness values are displayed on a three-dimensional pinwheel, highlighting the wide range of possible fitness effects of a single sequence step. The profiles of the pinwheels are similar, indicating the correlation of fitness landscapes, even if WT sequences (centers of the wheels) are only 40% identical and widely separated. Principal component analysis demonstrates a correlation between experimental fitness landscapes and amino-acid preferences in evolved sequences. |
||
Date | 5/2/2020 | ||
Source | Author supplied | ||
Author | Deepesh Nagarajan | ||
Permission
( Reusing this file ) |
I, the copyright holder of this work, hereby publish it under the following licenses:
This file is licensed under the
Creative Commons
Attribution-Share Alike
Attribution-Share Alike 4.0 International
,
3.0 Unported
,
2.5 Generic
,
2.0 Generic
and
1.0 Generic
license.
You may select the license of your choice.
|
This media file is uncategorized.
Please help improve this media file by adding it to one or more categories, so it may be associated with related media files (
how?
), and so that it can be more easily found.
Please notify the uploader with
{{subst:Please link images|File:IGPS fitness landscapes.png}} ~~~~
|