Laron_syndrome_01.jpg
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| Description |
English:
Impact of insulin/IGF-1 signaling in Laron syndrome (A) and Western diet (B) on FoxO-mediated gene regulation and associated pathologies. GHR*, growth hormone receptor loss of function mutation in Laron syndrome; GIP, glucose-dependent insulinotropic polypeptide, a whey protein-induced incretin, which stimulates β-cell proliferation and insulin secretion; PRL, prolactin; PRL secretion is induced by serotoninergic hypothalamic signaling; Trp, tryptophan, and Leu, leucine, essential amino acids enriched in the whey protein α-lactalbumin; Trp via serotonin synthesis stimulates pituitary GH and PRL secretion and Leu stimulates β-cell proliferation and insulin secretion.
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| Date | published 24 June 2011 |
| Source | B. C. Melnik, S. M. John, G. Schmitz: Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndrome. In: Nutrition & metabolism Band 8, 2011, p. 41, ISSN 1743-7075 . doi : 10.1186/1743-7075-8-41 . PMID 21699736 . |
| Author | B. C. Melnik, S. M. John, G. Schmitz |
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