Signal_transduction_v1.png
Summary
File:Signal transduction pathways.svg
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File:Signal transduction pathways (zh-cn).svg
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Description Signal transduction v1.png | Signal transduction pathways. Picture is a new version of old figure self-made in illustrator. |
Date | 22 March 2007 (original upload date) |
Source |
Originally from {Molecular cell biology. Lodish, Harvey 5 ed: - New York : W. H. Freeman and Co., 2003, 973 s. b ill. ISBN: 0-7167-4366-3. Libris: 8926100. The Hallmarks of Cancer, Douglas Hanahan and Robert A. Weinberg, Cell, Vol. 100, 57–70, January 7, 2000. http://www.weizmann.ac.il/home/fedomany/Bioinfo05/lecture6_Hanahan.pdf |
Author | Roadnottaken at English Wikipedia |
Other versions | Derivative works of this file: Signal transduction pathways (zh-cn).svg |
Involved proteins and Wikipedia links
--> = stimulation
--| = inhibition
Pathways involved:
en:Growth factors
-->RTK
en:Receptor tyrosine kinase
-->
en:Grb2
, SOS
en:Son of Sevenless
-->
en:Ras
-->
Raf
-->MEK
en:MAPK
/
ERK kinase
-->
en:MAPK
-->
Jun
,
en:Mad:Max
-->
ERK
-->Fos
en:C-fos
MEK -->
en:MEKK
-->
en:Myc:Max
PLC
en:phospholipase C
-->PKC
en:protein kinase c
-->
Raf
en:Ras
-->
en:Cdc42
-->
en:Rac
-->
en:Rho
Mos
en:c-Mos
-->MEK
en:MAPK
/
ERK kinase
ECM
en:Extracellular matrix
-->
en:Integrins
Integrins
-->
en:Cdc42
-->
en:PI3K
-->
en:Rac
-->
en:JNK
-->Jun
Integrins
-->
en:FAK
Src
-->Cas
en:CRK-associated substrate
-->
en:CRK
Integrins
-->
Fyn
Shc
en:Src homology 2 domain-containing
-->
en:Ras
Hormones,
e.g.
en:bombesin
-->
en:7TM
-receptor
-->G-prot
en:G-protein
-->
en:Ras
,
en:PI3K
, Ad cycl
en:Adenylate cyclase
-->PKA
en:protein kinase A
-->
en:CREB
e.g.
en:estrogen
-->
en:NHR
Survival factors
e.g.
en:IGF1
-->RTK
en:Receptor tyrosine kinase
-->
en:PI3K
-->PKC
en:Protein kinase C
-->
en:NF-kB
PI3K
-->
en:Akt
-->Akka
en:Akk-alpha
-->
en:IκB
-->NF-kB
Cytokines
-->Cytokine R
en:Cytokine
-Receptor
-->
en:Jaks
-->
Stats
-->
Bcl XL
--|
en:cytochrome c
Abnormality sensor
e.g.
Bim
-->Mt
en:Mitochondria
-->
en:cytochrome c
-->casp9
en:caspase 9
-->
en:apoptosis
Akt
--|Bad
en:Bcl-2-associated death promoter
--> Mt
en:Mitochondria
en:Decoy
Receptor
--|
en:Death factors
e.g.
FasL
en:Fas ligand
-->
Fas
-->
en:FADD
-->
en:caspase 8
-->apoptosis
caspase 8
-->
en:Bld
-->Mt
en:Mitochondria
-->apoptosis
FAP
en:Fas-associated phosphatase
--|
Fas
Changes in gene expression
-->
ARF
--|
en:MDM2
--|
en:p53
-->
Bax
-->Mt
en:Mitochondria
-->apoptosis
Antigrowth factors
e.g.
en:TGFβ
-->TGFβR
en:TGFβ receptors
-->
en:Smads
-->p15, p27]], p21
p15
--|cycl D
en:Cyclin D
CDK4
en:Cyclin-dependent kinase
4
--|Rb
en:Retinoblastoma protein
--|
en:E2F
p21
--|cycl E
en:Cyclin E
CDK2
en:Cyclin-dependent kinase
2
en:HPV E7 --|Rb en:Retinoblastoma protein
Hedgehog
--|Patched
-->
en:Smoothened
-->Gil
-->Changes in gene expression
en:Sufu
--> Gil
Wnt
-->
en:Frizzled
-->Dishevelled
-->
en:GSK-3β
-->
APC
-->
en:β-catenin
β-catenin + TCF
en:T-cell
factor
--> Gene expression
Licensing
Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License , Version 1.2 or any later version published by the Free Software Foundation ; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License . http://www.gnu.org/copyleft/fdl.html GFDL GNU Free Documentation License true true |
|
This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license. | |
Attribution: Roadnottaken | ||
|
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This licensing tag was added to this file as part of the GFDL licensing update . http://creativecommons.org/licenses/by-sa/3.0/ CC BY-SA 3.0 Creative Commons Attribution-Share Alike 3.0 true true |
Original upload log
(All user names refer to en.wikipedia)
- 2007-03-22 23:24 Roadnottaken 1858×1364×8 (259189 bytes) new version of old figure. self-made in illustrator. contact me for .AI file ~~~~
- 2007-03-22 23:18 Roadnottaken 1858×1364×8 (258214 bytes) fixed error in old figure. self-made in illustrator. (contact me for .AI file) ~~~~
- 2007-03-22 23:14 Roadnottaken 1858×1364×8 (251473 bytes) new version of old figure self-made in illustrator.