English: Scope of viral population dynamics. (A) Upon isolation from an infected host, a virus sample may (a) be adapted to cultured cells and subjected to large population or bottleneck transfers, (b) used for isolation for biological clones for further analysis, or (c) be adapted to a different host in vivo. (B) A quasispecies view of the events displayed in (A), following the type of representation depicted in Figure 1. Relevant adaptive mutations are highlighted with colored symbols. Figure adapted from ^[1] , with permission from the American Society for Microbiology, Washington DC, USA.