Viruses-07-02837-g002.png
Size of this preview:
800 × 435 pixels
.
Other resolutions:
320 × 174 pixels
|
640 × 348 pixels
|
1,024 × 556 pixels
|
1,280 × 695 pixels
|
3,161 × 1,717 pixels
.
Summary
| Description |
English:
Flaviviral replication complex assembled on the cytoplasmic side of the ER membrane. The viral replication complex is associated with the virus vesicle (single membrane vesicle) formed by invagination of the ER membrane. Interactions between flaviviral NS proteins are indicated schematically. Viral membrane proteins NS2A, NS2B, NS4A, and NS4B form a scaffold for the assembly of NS3 and NS5 proteins. Oligomerization of NS4A and dimerization of NS4B are depicted [51,52]. NS3 interacts with NS2B through its protease domain and with NS4B through its helicase domain. NS5 interacts only with NS3. The NS1 dimer is located in the ER lumen, and associates with NS4A and NS4B.
|
| Date | |
| Source |
Klema, V.J.; Padmanabhan, R.; Choi, K.H. Flaviviral Replication Complex: Coordination between RNA Synthesis and 5’-RNA Capping. Viruses 2015, 7, 4640-4656. https://www.mdpi.com/1999-4915/7/8/2837/htm |
| Author | Valerie J. Klema, Radhakrishnan Padmanabhan, and Kyung H. Choi |
Licensing
This file is licensed under the
Creative Commons
Attribution 4.0 International
license.
-
You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
-
Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.