downer
noun
[ ˈdaʊnə ]
• a depressant or tranquillizing drug, especially a barbiturate.
• "during that week I was heavily doped on downers"
• a dispiriting or depressing experience or factor.
• "the thought of the danger his son was in put something of a downer on the situation"
• a cow or other animal that has fallen down and cannot get to its feet unaided.