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vicissitude noun [ vɪˈsɪsɪtjuːd ]

• a change of circumstances or fortune, typically one that is unwelcome or unpleasant.
• "her husband's sharp vicissitudes of fortune"
Similar: change, alteration, alternation, transformation, metamorphosis, transmutation, mutation, modification, transition, development, shift, switch, turn, reversal, reverse, downturn, inconstancy, instability, uncertainty, unpredictability, chanciness, fickleness, variability, changeability, fluctuation, vacillation, ups and downs,
• alternation between opposite or contrasting things.
• "the vicissitude of the seasons"
Origin: early 17th century (in the sense ‘alternation’): from French, or from Latin vicissitudo, from vicissim ‘by turns’, from vic- ‘turn, change’.


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