Study suggests how the brain, with sleep, learns meaningful maps of spaces

Place cells are known to encode individual locations, but research finds stitching together a “cognitive map” of a whole environment requires a broader ensemble of cells, aided by sleep, over several days.

David Orenstein | The Picower Institute for Learning and Memory • mit
Jan. 10, 2025 ~8 min

New autism research projects represent a broad range of approaches to achieving a shared goal

At a symposium of the Simons Center for the Social Brain, six speakers described a diversity of recently launched studies aimed at improving understanding of the autistic brain.

David Orenstein | The Picower Institute for Learning and Memory • mit
Dec. 18, 2024 ~8 min


The way sensory prediction changes under anesthesia tells us how conscious cognition works

A new study adds evidence that consciousness requires communication between sensory and cognitive regions of the brain’s cortex.

David Orenstein | The Picower Institute for Learning and Memory • mit
Oct. 10, 2024 ~8 min

Research quantifying “nociception” could help improve management of surgical pain

New statistical models based on physiological data from more than 100 surgeries provide objective, accurate measures of the body’s subconscious perception of pain.

David Orenstein | The Picower Institute for Learning and Memory • mit
Sept. 24, 2024 ~10 min

Study assesses seizure risk from stimulating the thalamus

In animal models, even low stimulation currents can sometimes still cause electrographic seizures, researchers found.

David Orenstein | The Picower Institute for Learning and Memory • mit
Sept. 6, 2024 ~5 min

Study reveals ways in which 40Hz sensory stimulation may preserve brain’s “white matter”

Gamma frequency light and sound stimulation preserves myelination in mouse models and reveals molecular mechanisms that may underlie the benefit.

David Orenstein | The Picower Institute for Learning and Memory • mit
Aug. 13, 2024 ~9 min

New method enables fast, accurate estimates of cardiovascular state to inform blood pressure management

A mathematical method, validated with experimental data, provides a fast, reliable, and minimally invasive way of determining how to treat critical blood pressure changes during surgery or intensive care.

David Orenstein | The Picower Institute for Learning and Memory • mit
July 30, 2024 ~7 min

Study across multiple brain regions discerns Alzheimer’s vulnerability and resilience factors

Genomics and lab studies reveal numerous findings, including a key role for Reelin amid neuronal vulnerability, and for choline and antioxidants in sustaining cognition.

David Orenstein | The Picower Institute for Learning and Memory • mit
July 24, 2024 ~11 min


Study reveals how an anesthesia drug induces unconsciousness

Propofol, a drug commonly used for general anesthesia, derails the brain’s normal balance between stability and excitability.

Anne Trafton | MIT News • mit
July 15, 2024 ~8 min

Technologies enable 3D imaging of whole human brain hemispheres at subcellular resolution

Three innovations by an MIT-based team enable high-resolution, high-throughput imaging of human brain tissue at a full range of scales, and mapping connectivity of neurons at single-cell resolution.

David Orenstein | The Picower Institute for Learning and Memory • mit
June 17, 2024 ~12 min

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