Regulating the regulators

Tiny microRNAs help destroy unwanted messenger RNAs in cells. New research finds how the body keeps them in check.

Eva Frederick | Whitehead Institute • mit
Nov. 24, 2020 ~6 min

genetics crispr biology rna research whitehead-institute

Why we didn't get a vaccine by Election Day – but why we may get one soon

With COVID-19 cases soaring across the US and worldwide, the need for a vaccine could not be greater. With some half-dozen vaccines in phase 3 trials, why wasn't one ready before Election Day?

William Petri, Professor of Medicine, University of Virginia • conversation
Nov. 10, 2020 ~9 min

 covid-19  coronavirus  pandemic  rna  vaccines  pfizer  moderna  emergency-use-authorization  astrazeneca

Silencing gene expression to cure complex diseases

Immuneering uses bioinformatics to develop new medicines while also helping large pharmaceutical companies improve their treatments.

Zach Winn | MIT News Office • mit
Oct. 26, 2020 ~9 min

health medicine genetics cancer startups biology rna alzheimers data disease research drug-development school-of-engineering innovation-and-entrepreneurship-ie alumniae biological-engineering

Analyzing toehold sequences for synthetic biology

Computational algorithms enable identification and optimization of RNA-based tools for myriad applications.

Lindsay Brownell • harvard
Oct. 7, 2020 ~16 min

science-technology dna synthetic-biology rna wyss-institute james-collins

Nanoparticles can turn off genes in bone marrow cells

Using these new particles, researchers could develop treatments for heart disease and other conditions.

Anne Trafton | MIT News Office • mit
Oct. 5, 2020 ~8 min

genetics rna research school-of-engineering nanoscience-and-nanotechnology koch-institute institute-for-medical-engineering-and-science-imes chemical-engeering

Potential drug could ‘jam’ hand, foot, and mouth disease

Targeting RNA with small molecules could pave the way for new antivirals, in particular a drug for hand, foot, and mouth disease.

Robin Smith-Duke • futurity
Sept. 24, 2020 ~6 min

rna viruses drug-development health-and-medicine

Scientists discover new rules about “runaway” transcription

Findings related to bacterial gene expression overturn fundamental assumptions about basic biological pathways.

Raleigh McElvery | Department of Biology • mit
Sept. 2, 2020 ~7 min

dna physics genetics bacteria biology rna research school-of-science

The COVID-19 virus can spread through the air – here's what it'll take to detect the airborne particles

Miniaturized laboratory equipment is making it easier to identify airborne pathogens in the field, but there's still work ahead to be able to instantly determine if a room is safe or contaminated.

Shantanu Sur, Associate Professor of Biology, Clarkson University • conversation
Aug. 14, 2020 ~9 min

dna covid-19 coronavirus pandemic rna sars-cov-2 viruses pathogens star-trek airborne-virus metagenomics next-generation-sequencing pcr

Bringing RNA into genomics

ENCODE consortium identifies RNA sequences that are involved in regulating gene expression.

Anne Trafton | MIT News Office • mit
July 29, 2020 ~7 min

genetics biology rna research school-of-science

Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA

Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons.

David Orenstein | Picower Institute for Learning and Memory • mit
July 21, 2020 ~7 min

neuroscience rna immunology broad-institute research cells school-of-science brain-and-cognitive-sciences computer-science-and-artificial-intelligence-laboratory-csail picower-institute huntingtons

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