Basic cell health systems wear down in Huntington’s disease, analysis shows

A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis.

David Orenstein | Picower Institute for Learning and Memory • mit
Feb. 24, 2021 ~6 min

A high-resolution glimpse of gene expression in cells

Expanding tissue samples before sequencing allows researchers to pinpoint locations of RNA molecules.

Anne Trafton | MIT News Office • mit
Jan. 28, 2021 ~7 min

Why it takes 2 shots to make mRNA vaccines do their antibody-creating best – and what the data shows on delaying the booster dose

With slow vaccine distribution and manufacturing, some people won't get the second dose on time. But does it matter?

William Petri, Professor of Medicine, University of Virginia • conversation
Jan. 28, 2021 ~6 min

Progeria study finds base-editing therapy lengthens lifespan in mice

Several hundred children worldwide live with progeria, a deadly premature aging disease.

Caitlin McDermott-Murphy • harvard
Jan. 27, 2021 ~9 min

RNA molecules are masters of their own destiny

Research suggests the products of transcription — RNA molecules — regulate their own production through a feedback loop.

Eva Frederick | Whitehead Institute • mit
Jan. 5, 2021 ~8 min

3 Questions: Phillip Sharp on the discoveries that enabled RNA vaccines for Covid-19

Curiosity-driven basic science in the 1970s laid the groundwork for today’s leading vaccines against the novel coronavirus.

School of Science • mit
Dec. 11, 2020 ~9 min

Regulating the regulators

Tiny microRNAs help destroy unwanted messenger RNAs in cells. New research finds how the body keeps them in check.

Eva Frederick | Whitehead Institute • mit
Nov. 24, 2020 ~6 min

Why we didn't get a vaccine by Election Day – but why we may get one soon

With COVID-19 cases soaring across the US and worldwide, the need for a vaccine could not be greater. With some half-dozen vaccines in phase 3 trials, why wasn't one ready before Election Day?

William Petri, Professor of Medicine, University of Virginia • conversation
Nov. 10, 2020 ~9 min

Silencing gene expression to cure complex diseases

Immuneering uses bioinformatics to develop new medicines while also helping large pharmaceutical companies improve their treatments.

Zach Winn | MIT News Office • mit
Oct. 26, 2020 ~9 min

Analyzing toehold sequences for synthetic biology

Computational algorithms enable identification and optimization of RNA-based tools for myriad applications.

Lindsay Brownell • harvard
Oct. 7, 2020 ~16 min

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