MIT-led team receives funding to pursue new treatments for metabolic disease

Awarded $65.67 million from ARPA-H, the researchers will work to develop ingestible capsules that deliver mRNA and electric stimuli to treat metabolic disorders such as diabetes.

Anne Trafton | MIT News • mit
Feb. 5, 2024 ~6 min

Noninvasive technique reveals how cells’ gene expression changes over time

MIT researchers can now track a cell’s RNA expression to investigate long-term processes like cancer progression or embryonic development.

Anne Trafton | MIT News • mit
Jan. 10, 2024 ~7 min


Drugs of the future will be easier and faster to make, thanks to mRNA – after researchers work out a few remaining kinks

The COVID-19 pandemic demonstrated the promise of using mRNA as medicine. But before mRNA drugs can go beyond vaccines, researchers need to identify the right diseases to treat.

Li Li, Assistant Professor of Biomedical Sciences, UMass Chan Medical School • conversation
Jan. 4, 2024 ~9 min

Nanoparticle-delivered RNA reduces neuroinflammation in lab tests

MIT researchers find that in mice and human cell cultures, lipid nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s.

David Orenstein | Picower Institute • mit
Dec. 15, 2023 ~7 min

Customizing mRNA is easy, and that's what makes it the next frontier for personalized medicine − a molecular biologist explains

From COVID-19 vaccines to cancer treatments and beyond, the flexibility of mRNA-based therapies gives them the potential to prevent and treat many types of diseases.

Angie Hilliker, Associate Professor of Biology, University of Richmond • conversation
Dec. 12, 2023 ~9 min

MicroRNA is the master regulator of the genome − researchers are learning how to treat disease by harnessing the way it controls genes

When just one of the thousands of microRNAs in people go awry, it can cause diseases ranging from heart disease to cancer.

Andrea Kasinski, Associate Professor of Biological Sciences, Purdue University • conversation
Nov. 29, 2023 ~9 min

Search algorithm reveals nearly 200 new kinds of CRISPR systems

By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.

Allessandra DiCorato | Broad Institute • mit
Nov. 23, 2023 ~8 min

Can ‘listening in’ on cells speed up disease diagnosis?

A new device that "listens in" on cell conversations could lead to quicker, minimally invasive diagnoses for cancer and other diseases.

Brett Beasley-Notre Dame • futurity
Oct. 24, 2023 ~7 min


Thousands of programmable DNA-cutters found in algae, snails, and other organisms

New research finds RNA-guided enzymes called Fanzors are widespread among eukaryotic organisms.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
Oct. 13, 2023 ~6 min

Your immune system makes its own antiviral drug − and it's likely one of the most ancient

The human body has been making antivirals for eons, long before scientists did. A protein in your cells called viperin produces molecules that work similarly to the COVID-19 antiviral remdesivir.

Neil Marsh, Professor of Chemistry and Biological Chemistry, University of Michigan • conversation
Oct. 11, 2023 ~8 min

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