New method combines imaging and sequencing to study gene function in intact tissue

The approach collects multiple types of imaging and sequencing data from the same cells, leading to new insights into mouse liver biology.

Whitehead Institute • mit
June 30, 2025 ~9 min

AI model deciphers the code in proteins that tells them where to go

Whitehead Institute and CSAIL researchers created a machine-learning model to predict and generate protein localization, with implications for understanding and remedying disease.

Greta Friar | Whitehead Institute • mit
Feb. 13, 2025 ~11 min


Cellular traffic congestion in chronic diseases suggests new therapeutic targets

Chronic diseases like diabetes are prevalent, costly, and challenging to treat. A common denominator driving them may be a promising new therapeutic target.

Greta Friar | Whitehead Institute • mit
Dec. 10, 2024 ~10 min

CHARMed collaboration creates a potent therapy candidate for fatal prion diseases

A new gene-silencing tool shows promise as a future therapy against prion diseases and paves the way for new approaches to treating disease.

Greta Friar | Whitehead Institute • mit
June 27, 2024 ~12 min

Blood cell family trees trace how production changes with aging

Whitehead Institute Member Jonathan Weissman and collaborators developed a tool to reconstruct human cell family trees, revealing how blood cell production changes in old age.

Greta Friar | Whitehead Institute • mit
Jan. 31, 2024 ~11 min

Simons Center’s collaborative approach propels autism research, at MIT and beyond

Team-based targeted projects, multi-mentor fellowships ensure that scientists studying social cognition, behavior, and autism integrate multiple perspectives and approaches to pressing questions.

David Orenstein | Simons Center for the Social Brain • mit
Jan. 30, 2024 ~12 min

It takes three to tango: transcription factors bind DNA, protein, and RNA

Whitehead Institute researchers find many transcription factors bind RNA, which fine-tunes their regulation of gene expression, suggesting new therapeutic opportunities.

Greta Friar | Whitehead Institute • mit
July 17, 2023 ~7 min

Focus on function helps identify the changes that made us human

A new approach for identifying significant differences in gene use between closely-related species provides insights into human evolution.

Greta Friar | Whitehead Institute • mit
July 6, 2023 ~11 min


Inaugural J-WAFS Grand Challenge aims to develop enhanced crop variants and move them from lab to land

Matt Shoulders will lead an interdisciplinary team to improve RuBisCO — the photosynthesis enzyme thought to be the holy grail for improving agricultural yield.

Carolyn Blais | Abdul Latif Jameel Water and Food Systems Lab • mit
May 10, 2023 ~14 min

3 Questions: Mriganka Sur on researching the first approved drug to treat Rett syndrome

On March 10 the FDA approved Trofinetide, a drug based on the protein IGF-1. The MIT professor's original research showing that IGF-1 could treat Rett was published in 2009.

David Orenstein | Picower Institute for Learning and Memory • mit
March 13, 2023 ~9 min

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