How CRISPR technology is advancing

Fewer off-target edits and greater targeting scope bring gene editing technology closer to treating human diseases.

Caitlin McDermott-Murphy | Feb. 14, 2020 | harvard
~7 mins   

Tags: science-technology base-editing base-editors biotechnology-nature broad-institute caitlin-mcdermott-murphy cas9 chemistry chemistry-and-chemical-biology crispr david-liu dna gene-editing genetic-disease genetic-engineering genome rna sickle-cell-anemia

Study likens Earth’s evolution to creation of Frankenstein’s monster

The evolution of the first building blocks on Earth may have been messier than previously thought, likening it to the mishmash creation of Frankenstein’s monster.

Caitlin McDermott-Murphy | Jan. 28, 2020 | harvard
~4 mins   

Tags: science-technology primordial-soup basic-research caitlin-mcdermott-murphy chemistry chemistry-and-chemical-biology dna engineering genetics jack-szostak origins-of-life prebiotic rna science seohyun-kim

Evolution more complex than ‘survival of the fittest’ had us believe

By re-barcoding the DNA of yeast, researchers were able to follow evolution for approximately 1,000 generations, finding surprises along the way.

Clea Simon | Nov. 13, 2019 | harvard
~4 mins   

Tags: science-technology alex-n-nguyen-ba barcoding dna evolution ivana-cvijovic michael-desai organismic-and-evolutionary-biology physics yeast

Harvard researchers create DNA ‘propellers’

Understanding how DNA and proteins interact — or fail to — could help answer fundamental biological questions about human health and disease.

Caitlin McDermott-Murphy | July 19, 2019 | harvard
~7 mins   

Tags: science-technology biomechanics biotechnology cell-biology chemistry dna micromachines microscopy molecular-biology nanotechnology nature optics xiaowei-zhuang

Harvard doctoral students describe projects at the cutting edge of evolutionary inquiry

Harvard doctoral students offered a glimpse of the future of evolutionary inquiry, outlining projects that touch on the human pelvis, butterfly hybrids, field and forest mice, and the mystery of an ancient pile of bones.

Alvin Powell | April 22, 2019 | harvard
~9 mins   

Tags: science-technology alvin-powell ancient-dna andrew-berry butterfly eadaoin-harney emily-hager evolution harvard-museum-of-natural-history mariel-young mouse nate-edelman pelvis speciation

New tool calculates genetic risk for obesity

A “polygenic score” for obesity, a quantitative tool that predicts an individual’s inherited risk for becoming overweight, may identify an opportunity for early intervention.

Karen Zusi | April 18, 2019 | harvard
~6 mins   

Tags: health-medicine amit-v-khera avon-longitudinal-study-of-parents-and-children broad-institute clinical-interventions coronary-artery-risk-development-in-young-adults-study dna framingham-offspring-study genetic obesity polygenic-score polygenic-scoring uk-biobank

HMS researchers design algorithm that ID’s DNA defects, making more cancers treatable

A new algorithm designed by HMS scientists can be incorporated into standard genetic tests to successfully identify patients harboring a tumor-fueling DNA repair defect found in multiple cancers treatable with existing drugs.

Ekaterina Pesheva | April 15, 2019 | harvard
~10 mins   

Tags: health-medicine algorithm-ids-dna-defects blavatnik-institute brca-genes cancer-treatment-advance doga-gulhan genetic-panels harvard-medical-school hr-deficiency nature-genetics newly-designed-algorithm parp-inhibitors peter-park sigma

Harvard study unlocks a key to regeneration

Led by Assistant Professor of Organismic and Evolutionary Biology Mansi Srivastava, a team of researchers is shedding new light on how animals perform whole-body regeneration, and uncovering a number of DNA switches that appear to control genes used in the process.

Peter Reuell | March 14, 2019 | harvard
~9 mins   

Tags: science-technology andrew-gehrke dna early-growth-response egr faculty-of-arts-and-sciences fas gehrke genes harvard mansi-srivastava noncoding-dna peter-reuell regeneration reuell srivastava three-banded-panther-worms whole-body-regeneration worms

Science writers discuss ‘sideways’ DNA at Harvard

Science authors David Quammen and Carl Zimmer both have recent books showing that DNA is not only passed down from our ancestors but can also come from viruses, siblings, and even our children.

Clea Simon | March 1, 2019 | harvard
~5 mins   

Tags: science-technology carl-woese carl-zimmer david-quammen dna evolution-matters

Harvard researchers look toward nature to beat cancer

Every year, more than 18 million people around the world are told, “You have cancer.” In the U.S., nearly half of all men and more than one-third of women will develop some kind of cancer during their lifetimes, and 600,000-plus die from it annually. Despite the billions of dollars and countless new treatments that have […]

Lindsay Brownell | March 1, 2019 | harvard
~24 mins   

Tags: health-medicine artificial-lymph-nodes cancer-research-uks-grand-challenge cancer-treatments cancer-vaccine chemotherapy david-mooney dna-origami donald-ingber inflammation mimicking-nature nanoparticle-backpacks organ-chips samir-mitragotri william-shih wyss-institute

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