Controlling a DNA-synthesizing enzyme with photolithographic methods from the computer chip industry facilitates multiplexed writing and storage of digital data in DNA.
Oct. 19, 2020 • ~9 min
science-technology dna harvard-medical-school george-church wyss-institute
Wei Hsi “Ariel” Yeh dedicated her research in chemistry to solving some of the vast genetic mysteries behind hearing loss.
June 5, 2020 • ~6 min
science-technology dna chemistry crispr genome basic-research howard-hughes-medical-institute chemistry-and-chemical-biology rna gene-editing broad-institute caitlin-mcdermott-murphy deafness hearing-loss cas9 base-editing base-editors david-liu genetic-disease genetic-engineering sickle-cell-anemia progeria tmc1
In a study involving thousands of participants, a new blood test detected more than 50 types of cancer as well as their location within the body with a high degree of accuracy.
March 31, 2020 • ~4 min
dna cancer basic-research harvard-medical-school health-medicine annals-of-oncology grail pathfinder
Fewer off-target edits and greater targeting scope bring gene editing technology closer to treating human diseases.
Feb. 14, 2020 • ~7 min
science-technology dna chemistry crispr genome chemistry-and-chemical-biology rna gene-editing broad-institute caitlin-mcdermott-murphy cas9 base-editing base-editors biotechnology-nature david-liu genetic-disease genetic-engineering sickle-cell-anemia
The evolution of the first building blocks on Earth may have been messier than previously thought, likening it to the mishmash creation of Frankenstein’s monster.
Jan. 28, 2020 • ~4 min
science-technology engineering dna chemistry genetics basic-research chemistry-and-chemical-biology jack-szostak origins-of-life rna science caitlin-mcdermott-murphy primordial-soup prebiotic seohyun-kim
By re-barcoding the DNA of yeast, researchers were able to follow evolution for approximately 1,000 generations, finding surprises along the way.
Nov. 13, 2019 • ~4 min
science-technology dna evolution physics yeast organismic-and-evolutionary-biology alex-n-nguyen-ba barcoding ivana-cvijovic michael-desai
Understanding how DNA and proteins interact — or fail to — could help answer fundamental biological questions about human health and disease.
July 19, 2019 • ~7 min
science-technology dna chemistry biotechnology optics nanotechnology nature microscopy biomechanics cell-biology micromachines molecular-biology xiaowei-zhuang
A “polygenic score” for obesity, a quantitative tool that predicts an individual’s inherited risk for becoming overweight, may identify an opportunity for early intervention.
April 18, 2019 • ~6 min
dna obesity genetic health-medicine uk-biobank broad-institute amit-v-khera avon-longitudinal-study-of-parents-and-children clinical-interventions coronary-artery-risk-development-in-young-adults-study framingham-offspring-study polygenic-score polygenic-scoring