How CRISPR technology is advancing

Fewer off-target edits and greater targeting scope bring gene editing technology closer to treating human diseases.

Caitlin McDermott-Murphy | Feb. 14, 2020 | harvard
~7 mins   

Tags: science-technology base-editing base-editors biotechnology-nature broad-institute caitlin-mcdermott-murphy cas9 chemistry chemistry-and-chemical-biology crispr david-liu dna gene-editing genetic-disease genetic-engineering genome rna sickle-cell-anemia

Big step toward identifying all cancer-causing genetic mutations

An international team of 1,300 scientists has generated the most complete cancer genome map to date, bringing researchers closer to identifying all major cancer-causing genetic mutations.

Stephanie McPherson | Feb. 5, 2020 | harvard
~12 mins   

Tags: science-technology basic-research bioengineering broad-institute-of-mit-and-harvard cancer-genome-map cancer-causing-genetic-mutations engineering icgctcga-pan-cancer-analysis-of-whole-genomes-project pan-cancer-project whole-cancer-genomes

Gene flow between butterfly species offers clue to biodiversity

An analysis of 20 butterfly genomes found evidence that many butterfly species — including distantly related species — show a surprisingly high amount of gene flow between them, Harvard researchers found.

Peter Reuell | Oct. 31, 2019 | harvard
~6 mins   

Tags: science-technology butterfly edelman faculty-of-arts-and-sciences fas gene-flow genes genome genomes harvard heliconius hybrid hybridization introgression james-mallet mallet michael-miyagi miyagi nate-edelman peter-reuell reuell

76 more gene regions found associated with sleep duration

Scientists from Massachusetts General Hospital and the University of Exeter Medical School have identified another 76 gene regions associated with sleep duration. Their findings may underpin future investigations into disordered sleep and understanding individual set points for how much is enough.

Sue McGreevey | March 8, 2019 | harvard
~6 mins   

Tags: health-medicine early-riser genome-wide-association-study hassan-saeed-dashti massachusetts-general-hospital mgh nature-communications night-owl richa-saxena samuel-jones uk-biobank university-of-exeter-medical-school

Harvard researchers isolate new age-related biomarker

Harvard researchers have discovered that a novel biomarker of aging in rDNA can accurately determine an individual’s chronological and biological age. The biomarker opens new opportunities for monitoring responses to interventions and lifestyle choices.

Chris Sweeney | Feb. 14, 2019 | harvard
~5 mins   

Tags: health-medicine bernardo-lemos biological-age calorie-restricted-diet calorie-restricted-regimen chronological-age genome-research harvard-th-chan-school-of-public-health rdna ribosomal-dna

Benefits of being an early riser vs. a night owl

A new study finds that being genetically programmed to rise early may lead to greater well-being and a lower risk of schizophrenia and depression.

Louise Vennells | Jan. 29, 2019 | harvard
~5 mins   

Tags: health-medicine 23andme body-clock circadian-rhythm-disorders depression early-risers genome massachusetts-general-hospital mental-disease mental-health nature-communications night-owls retina university-of-exeter

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