Scientists discover potential new targets for Alzheimer’s drugs

Pathways involved in DNA repair and other cellular functions could contribute to the development of Alzheimer’s.

Anne Trafton | MIT News • mit
May 20, 2025 ~7 min

A brief history of expansion microscopy

Since an MIT team introduced expansion microscopy in 2015, the technique has powered the science behind kidney disease, plant seeds, the microbiome, Alzheimer’s, viruses, and more.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
April 23, 2025 ~13 min


Evidence that 40Hz gamma stimulation promotes brain health is expanding

A decade of studies provide a growing evidence base that increasing the power of the brain’s gamma rhythms could help fight Alzheimer’s, and perhaps other neurological diseases.

David Orenstein | The Picower Institute for Learning and Memory • mit
March 14, 2025 ~6 min

Designing better ways to deliver drugs

Graduate student and MathWorks fellow Louis DeRidder is developing a device to make chemotherapy dosing more accurate for individual patients.

Michaela Jarvis | School of Engineering • mit
March 4, 2025 ~7 min

Seeing more in expansion microscopy

New methods light up lipid membranes and let researchers see sets of proteins inside cells with high resolution.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
March 3, 2025 ~10 min

New open-source tool helps to detangle the brain

The software tool NeuroTrALE is designed to quickly and efficiently process large amounts of brain imaging data semi-automatically.

Anne McGovern | MIT Lincoln Laboratory • mit
Aug. 14, 2024 ~8 min

Study reveals ways in which 40Hz sensory stimulation may preserve brain’s “white matter”

Gamma frequency light and sound stimulation preserves myelination in mouse models and reveals molecular mechanisms that may underlie the benefit.

David Orenstein | The Picower Institute for Learning and Memory • mit
Aug. 13, 2024 ~9 min

Study across multiple brain regions discerns Alzheimer’s vulnerability and resilience factors

Genomics and lab studies reveal numerous findings, including a key role for Reelin amid neuronal vulnerability, and for choline and antioxidants in sustaining cognition.

David Orenstein | The Picower Institute for Learning and Memory • mit
July 24, 2024 ~11 min


Technologies enable 3D imaging of whole human brain hemispheres at subcellular resolution

Three innovations by an MIT-based team enable high-resolution, high-throughput imaging of human brain tissue at a full range of scales, and mapping connectivity of neurons at single-cell resolution.

David Orenstein | The Picower Institute for Learning and Memory • mit
June 17, 2024 ~12 min

Study: Movement disorder ALS and cognitive disorder FTLD show strong molecular overlaps

Single-cell gene expression patterns in the brain, and evidence from follow-up experiments, reveal many shared cellular and molecular similarities that could be targeted for potential treatment.

David Orenstein | The Picower Institute for Learning and Memory • mit
March 22, 2024 ~9 min

/

7