40 Hz vibrations reduce Alzheimer’s pathology, symptoms in mouse models

Tactile stimulation improved motor performance, reduced phosphorylated tau, preserved neurons and synapses, and reduced DNA damage, a new study shows.

David Orenstein | The Picower Institute for Learning and Memory • mit
June 5, 2023 ~7 min

Researchers map brain cell changes in Alzheimer’s disease

Study reveals key cell structures and gene expression changes near amyloid plaques and tau tangles in mouse brain tissue.

Allessandra DiCorato | Broad Institute • mit
Feb. 2, 2023 ~7 min


New technologies reveal cross-cutting breakdowns in Alzheimer’s disease

“Single-cell profiling” is helping neuroscientists see how disease affects major brain cell types and identify common, potentially targetable pathways.

David Orenstein | Picower Institute for Learning and Memory • mit
Jan. 18, 2023 ~6 min

Small studies of 40-hertz sensory stimulation confirm safety, suggest Alzheimer’s benefits

MIT researchers report early-stage clinical study results of tests with noninvasive 40-hertz light and sound treatment.

David Orenstein | Picower Institute for Learning and Memory • mit
Dec. 13, 2022 ~9 min

Alzheimer’s risk gene undermines insulation of brain’s “wiring”

In people carrying APOE4, a key brain cell mismanages cholesterol needed to insulate neurons properly — another sign APOE4 contributes to disease by disrupting brain lipids.

David Orenstein | Picower Institute for Learning and Memory • mit
Nov. 22, 2022 ~8 min

A “door” into the mitochondrial membrane

Study finds the protein MTCH2 is responsible for shuttling various other proteins into the membrane of mitochondria. The finding could have implications for cancer treatments and MTCH2-linked conditions.

Eva Frederick | Whitehead Institute • mit
Oct. 25, 2022 ~7 min

Celebrating 20 years of discovery, Picower Institute looks ahead to continuing impact

At an exhibition marking two decades since a transformative gift from the Picower Foundation, current and alumni members described research at the forefront of neuroscience and beyond.

David Orenstein | Picower Institute for Learning and Memory • mit
Oct. 12, 2022 ~15 min

With fractured genomes, Alzheimer’s neurons call for help

Study indicates ailing neurons may instigate an inflammatory response from the brain’s microglia immune cells.

David Orenstein | Picower Institute for Learning and Memory • mit
Oct. 4, 2022 ~8 min


Neurodegenerative disease can progress in newly identified patterns

A machine-learning method finds patterns of health decline in ALS, informing future clinical trial designs and mechanism discovery. The technique also extends to Alzheimer’s and Parkinson’s.

Lauren Hinkel | MIT-IBM Watson AI Lab • mit
Sept. 27, 2022 ~10 min

When Alzheimer’s degrades cells that cross hemispheres, visual memory suffers

Research reveals cells that span brain hemispheres to coordinate activity in visual processing centers, shows Alzheimer’s degrades their structure and function.

David Orenstein | Picower Institute for Learning and Memory • mit
Aug. 24, 2022 ~7 min

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