Scientists develop a rapid gene-editing screen to find effects of cancer mutations

With the new technique, MIT researchers hope to identify mutations that could be targeted with new cancer therapies.

Anne Trafton | MIT News • mit
March 12, 2024 ~9 min

Search algorithm reveals nearly 200 new kinds of CRISPR systems

By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.

Allessandra DiCorato | Broad Institute • mit
Nov. 23, 2023 ~8 min


Thousands of programmable DNA-cutters found in algae, snails, and other organisms

New research finds RNA-guided enzymes called Fanzors are widespread among eukaryotic organisms.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
Oct. 13, 2023 ~6 min

Focus on function helps identify the changes that made us human

A new approach for identifying significant differences in gene use between closely-related species provides insights into human evolution.

Greta Friar | Whitehead Institute • mit
July 6, 2023 ~11 min

Researchers uncover a new CRISPR-like system in animals that can edit the human genome

The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR/Cas systems.

Leah Eisenstadt | McGovern Institute for Brain Research | Broad Institute • mit
June 28, 2023 ~7 min

Gene-editing technique could speed up study of cancer mutations

With the new method, scientists can explore many cancer mutations whose roles are unknown, helping them develop new drugs that target those mutations.

Anne Trafton | MIT News Office • mit
May 11, 2023 ~9 min

A new control switch could make RNA therapies easier to program

Using this approach, researchers hope to deliver therapeutic RNA molecules selectively to cancer cells or other target cells.

Anne Trafton | MIT News Office • mit
March 15, 2023 ~7 min

New CRISPR-based tool inserts large DNA sequences at desired sites in cells

Known as PASTE, the technique holds potential for treating a variety of diseases caused by faulty genes.

Anne Trafton | MIT News Office • mit
Nov. 24, 2022 ~8 min


Scientists unveil the functional landscape of essential genes

Researchers harness new pooled, image-based screening method to probe the functions of over 5,000 essential genes in human cells.

Nicole Davis | Whitehead Institute • mit
Nov. 21, 2022 ~6 min

A new control system for synthetic genes

Researchers have developed a technique that could help fine-tune the production of monoclonal antibodies and other useful proteins.

Anne Trafton | MIT News Office • mit
Nov. 1, 2022 ~7 min

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