Nature-inspired CRISPR enzymes for expansive genome editing

Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences.

Media Lab • mit
May 19, 2020 ~6 min

Tags: dna crispr covid-19 rna research computational-biology media-lab school-of-architecture-and-planning alumniae genome-editing center-for-bits-and-atoms

Using gene editing, neuroscientists develop a new model for autism

By introducing a gene variant associated with autism into monkeys, researchers hope to study treatment options for severe neurodevelopmental disorders.

Anne Trafton | MIT News Office • mit
June 12, 2019 ~9 min

Tags: crispr neuroscience autism china broad-institute research school-of-engineering school-of-science brain-and-cognitive-sciences mcgovern-institute genome-editing

New gene-editing system precisely inserts large DNA sequences into cellular DNA

Researchers identify and develop new CRISPR-associated transposase system for targeted integration of DNA, adding key capabilities to gene-editing technology.

Karen Zusi | Broad Institute • mit
June 12, 2019 ~7 min

Tags: dna genetics crispr rna broad-institute research school-of-engineering school-of-science brain-and-cognitive-sciences biological-engineering mcgovern-institute genome-editing

New CRISPR tool opens up more of the genome for editing

Enzyme can target almost half of the genome’s “ZIP codes” and could enable editing of many more disease-specific mutations.

Helen Knight | MIT News correspondent • mit
Oct. 24, 2018 ~6 min

Tags: dna genetics crispr rna research media-lab school-of-architecture-and-planning biological-engineering genome-editing

Researchers advance CRISPR-based tool for diagnosing disease | MIT News

With SHERLOCK, a strip of paper can now indicate presence of pathogens, tumor DNA, or any genetic signature of interest.

Broad Institute • mit
Feb. 15, 2018 ~6 min

Tags:  dna  medicine  genetics  crispr  cancer  rna  broad-institute  disease  research  school-of-engineering  school-of-science  brain-and-cognitive-sciences  biological-engineering  health-sciences-and-technology  mcgovern-institute  genome-editing

Reading and writing DNA | MIT News

Department of Biology kicks off IAP seminar series with a lecture by synthetic-biology visionary George Church.

Raleigh McElvery | Department of Biology • mit
Jan. 31, 2018 ~8 min

Tags:  dna  genetics  crispr  bacteria  industry  biology  synthetic-biology  health-care  broad-institute  research  school-of-science  innovation-and-entrepreneurship-ie  biological-engineering  independent-activities-period  genome-editing

Researchers engineer CRISPR to edit single RNA letters in human cells | MIT News

“REPAIR” system edits RNA, rather than DNA; has potential to treat diseases without permanently affecting the genome.

Broad Institute • mit
Oct. 25, 2017 ~6 min

Tags:  dna  genetics  crispr  rna  broad-institute  research  school-of-engineering  school-of-science  harvard-mit-health-sciences-and-technology  brain-and-cognitive-sciences  biological-engineering  mcgovern-institute  genome-editing

Gene-editing technology developer Feng Zhang awarded $500,000 Lemelson-MIT Prize | MIT News

MIT associate professor and member of the Broad Institute and McGovern Institute recognized for commitment to invention, collaboration, and mentorship.

Lemelson-MIT Program • mit
Sept. 19, 2017 ~5 min

Tags:  dna  genetics  crispr  broad-institute  invention  awards-honors-and-fellowships  lemelson-mit  school-of-engineering  school-of-science  faculty  brain-and-cognitive-sciences  biological-engineering  mcgovern-institute  genome-editing

Feng Zhang to share Albany Medical Prize | MIT News

Five recipients honored for their fundamental and complementary accomplishments related to CRISPR-Cas9.

McGovern Institute for Brain Research • mit
Aug. 15, 2017 ~2 min

Tags:  dna  genetics  crispr  broad-institute  awards  research  awards-honors-and-fellowships  school-of-engineering  school-of-science  faculty  brain-and-cognitive-sciences  biological-engineering  mcgovern-institute  genome-editing

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