Search algorithm reveals nearly 200 new kinds of CRISPR systems

By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.

Allessandra DiCorato | Broad Institute • mit
Nov. 23, 2023 ~8 min

Thousands of programmable DNA-cutters found in algae, snails, and other organisms

New research finds RNA-guided enzymes called Fanzors are widespread among eukaryotic organisms.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
Oct. 13, 2023 ~6 min


A more effective experimental design for engineering a cell into a new state

By focusing on causal relationships in genome regulation, a new AI method could help scientists identify new immunotherapy techniques or regenerative therapies.

Adam Zewe | MIT News • mit
Oct. 2, 2023 ~8 min

New CRISPR-based map ties every human gene to its function

Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell.

Eva Frederick | Whitehead Institute • mit
June 9, 2022 ~9 min

Convenience-sized RNA editing

MIT neuroscientists expand CRISPR toolkit with new, compact Cas7-11 enzyme.

Sarah CP Williams | McGovern Institute for Brain Research • mit
May 31, 2022 ~6 min

Using plant biology to address climate change

A Climate Grand Challenges flagship project aims to reduce agriculture-driven emissions while making food crop plants heartier and more nutritious.

Merrill Meadow | Whitehead Institute • mit
April 19, 2022 ~9 min

New programmable gene editing proteins found outside of CRISPR systems

Researchers find RNA-guided enzymes are more diverse and widespread than previously believed.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
Sept. 15, 2021 ~6 min

Scientists harness human protein to deliver molecular medicines to cells

Made of components found in the human body, the programmable system is a step toward safer, targeted delivery of gene editing and other molecular therapeutics.

Broad Institute • mit
Aug. 19, 2021 ~8 min


A new technique for correcting disease-causing mutations

Novel method, developed by McGovern Institute researchers, may lead to safer, more efficient gene therapies.

Jill Crittenden | McGovern Institute for Brain Research • mit
June 9, 2021 ~7 min

Nature-inspired CRISPR enzymes for expansive genome editing

Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences.

Media Lab • mit
May 19, 2020 ~6 min

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