Alzheimer’s risk gene undermines insulation of brain’s “wiring”
In people carrying APOE4, a key brain cell mismanages cholesterol needed to insulate neurons properly — another sign APOE4 contributes to disease by disrupting brain lipids.
David Orenstein | Picower Institute for Learning and Memory •
mit
Nov. 22, 2022 • ~8 min
Nov. 22, 2022 • ~8 min
Celebrating 20 years of discovery, Picower Institute looks ahead to continuing impact
At an exhibition marking two decades since a transformative gift from the Picower Foundation, current and alumni members described research at the forefront of neuroscience and beyond.
David Orenstein | Picower Institute for Learning and Memory •
mit
Oct. 12, 2022 • ~15 min
Oct. 12, 2022 • ~15 min
When Alzheimer’s degrades cells that cross hemispheres, visual memory suffers
Research reveals cells that span brain hemispheres to coordinate activity in visual processing centers, shows Alzheimer’s degrades their structure and function.
David Orenstein | Picower Institute for Learning and Memory •
mit
Aug. 24, 2022 • ~7 min
Aug. 24, 2022 • ~7 min
New findings reveal how neurons build and maintain their capacity to communicate
Nerve cells regulate and routinely refresh the collection of calcium channels that enable them to send messages across circuit connections.
David Orenstein | Picower Institute for Learning and Memory •
mit
July 21, 2022 • ~8 min
July 21, 2022 • ~8 min
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