A single memory is stored across many connected brain regions

Innovative brain-wide mapping study shows that an “engram,” the ensemble of neurons encoding a memory, is widely distributed and includes regions not previously realized.

David Orenstein | Picower Institute for Learning and Memory • mit
May 2, 2022 ~9 min

Neurons are fickle. Electric fields are more reliable for information.

Electric fields may represent information held in working memory, allowing the brain to overcome “representational drift,” or the inconsistent participation of individual neurons.

David Orenstein | Picower Institute for Learning and Memory • mit
April 4, 2022 ~7 min


“Traveling” nature of brain waves may help working memory work

The act of holding information in mind is accompanied by coordination of rotating brain waves in the prefrontal cortex, a phenomenon that may convey specific advantages, a new study suggests.

David Orenstein | Picower Institute for Learning and Memory • mit
Feb. 10, 2022 ~7 min

Study links gene to cognitive resilience in the elderly

The findings may help explain why some people who lead enriching lives are less prone to Alzheimer’s and age-related dementia.

Anne Trafton | MIT News Office • mit
Nov. 3, 2021 ~6 min

Brain’s “memory center” is needed to recognize image sequences, but not single sights

The visual cortex stores and remembers individual images, but mice can’t recognize image sequences without guidance from the hippocampus.

David Orenstein | Picower Institute for Learning and Memory • mit
July 26, 2021 ~7 min

Memory-making involves extensive DNA breaking

To quickly express learning and memory genes, brain cells snap both strands of DNA in many more places and cell types than previously realized, a new study shows.

David Orenstein | Picower Institute for Learning and Memory • mit
July 14, 2021 ~7 min

As novel sights become familiar, different brain rhythms and neurons take over

As “visual recognition memory” emerges in the visual cortex, one circuit of inhibitory neurons supplants another, and slower neural oscillations prevail.

David Orenstein | Picower Institute for Learning and Memory • mit
June 24, 2021 ~6 min

How the brain helps us remember what we’ve seen

Research finds that as one looks around, mental images bounce between right and left brain as they shift around in our visual system.

David Orenstein | Picower Institute for Learning and Memory • mit
Feb. 8, 2021 ~8 min


Neuroscientists identify brain circuit that encodes timing of events

Findings suggest this hippocampal circuit helps us to maintain our timeline of memories.

Anne Trafton | MIT News Office • mit
Jan. 11, 2021 ~6 min

Neuroscientists discover a molecular mechanism that allows memories to form

Modifications to chromosomes in “engram” neurons control the encoding and retrieval of memories.

Anne Trafton | MIT News Office • mit
Oct. 5, 2020 ~7 min

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