Live imaging method brings structure to mapping brain function

Scientists distinguish brain regions based on what they do, but now have a new way to overlay information about how they are built.

David Orenstein | Picower Institute for Learning and Memory • mit
Sept. 24, 2020 ~6 min

Tags: neuroscience imaging microscopy vision research school-of-science brain-and-cognitive-sciences picower-institute 3-d-imaging

As information flows through brain’s heirarchy, higher regions use higher-frequency waves

Study also finds specific frequency bands of brain waves associated with encoding, or inhibiting encoding, of sensory information across the cortex.

David Orenstein | Picower Institute for Learning and Memory • mit
Sept. 10, 2020 ~6 min

Tags: neuroscience memory research school-of-science brain-and-cognitive-sciences picower-institute

Study suggests animals think probabilistically to distinguish contexts

New statistical model may help scientists understand how animals infer whether surroundings are novel or haven’t changed enough to be a new context.

David Orenstein | Picower Institute for Learning and Memory • mit
Aug. 12, 2020 ~6 min

Tags: biology memory research behavior school-of-science brain-and-cognitive-sciences center-for-brains-minds-and-machines picower-institute

Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA

Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons.

David Orenstein | Picower Institute for Learning and Memory • mit
July 21, 2020 ~7 min

Tags: neuroscience rna immunology broad-institute research cells school-of-science brain-and-cognitive-sciences computer-science-and-artificial-intelligence-laboratory-csail picower-institute huntingtons

Findings weaken notion that size equals strength for neural connections

Among study’s many surprises may be a new way to address Fragile X syndrome — by finding a “protein X.”

David Orenstein | Picower Institute for Learning and Memory • mit
July 14, 2020 ~5 min

Tags: neuroscience autism research school-of-science brain-and-cognitive-sciences synapses picower-institute

How worms move: Dopamine helps nematodes coordinate motor behaviors

To spy on worms for days on end, Picower Institute scientists invent a new open-source microscopy platform.

David Orenstein | Picower Institute for Learning and Memory • mit
June 30, 2020 ~8 min

Tags: neuroscience microscopy animals research school-of-science brain-and-cognitive-sciences national-science-foundation-nsf national-institutes-of-health-nih picower-institute

Like a treasure map, brain region emphasizes reward location

The lateral septum encodes spatial information with a special emphasis on where the reward lies.

David Orenstein | Picower Institute for Learning and Memory • mit
June 23, 2020 ~4 min

Tags: neuroscience biology memory learning research school-of-science brain-and-cognitive-sciences picower-institute

Study finds path for addressing Alzheimer’s blood-brain barrier impairment

MIT researchers pinpoint mechanism and demonstrate that drugs could help.

David Orenstein | Picower Institute for Learning and Memory • mit
June 15, 2020 ~7 min

Tags: stem-cells medicine neuroscience alzheimers tissue-engineering research drug-development school-of-science brain-and-cognitive-sciences picower-institute

Research highlights immune molecule’s complex role in Huntington’s disease

Knocking out the immune cytokine IL-6 exacerbates symptoms in HD model mice, affects neural connection genes.

David Orenstein | Picower Institute for Learning and Memory • mit
June 8, 2020 ~4 min

Tags: neuroscience immunology broad-institute disease research school-of-science brain-and-cognitive-sciences picower-institute

Making tissue stretchable, compressible, and nearly indestructible

Chemical process called ELAST allows labeling probes to infuse more quickly, and makes samples tough enough for repeated handling.

David Orenstein | Picower Institute for Learning and Memory • mit
May 20, 2020 ~7 min

Tags: neuroscience imaging microscopy tissue-engineering research school-of-engineering national-institutes-of-health-nih institute-for-medical-engineering-and-science-imes picower-institute chemical-engineering

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