Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA

Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons.

David Orenstein | Picower Institute for Learning and Memory • mit
July 21, 2020 ~7 min

Findings weaken notion that size equals strength for neural connections

Among study’s many surprises may be a new way to address Fragile X syndrome — by finding a “protein X.”

David Orenstein | Picower Institute for Learning and Memory • mit
July 14, 2020 ~5 min


How worms move: Dopamine helps nematodes coordinate motor behaviors

To spy on worms for days on end, Picower Institute scientists invent a new open-source microscopy platform.

David Orenstein | Picower Institute for Learning and Memory • mit
June 30, 2020 ~8 min

Like a treasure map, brain region emphasizes reward location

The lateral septum encodes spatial information with a special emphasis on where the reward lies.

David Orenstein | Picower Institute for Learning and Memory • mit
June 23, 2020 ~4 min

Study finds path for addressing Alzheimer’s blood-brain barrier impairment

MIT researchers pinpoint mechanism and demonstrate that drugs could help.

David Orenstein | Picower Institute for Learning and Memory • mit
June 15, 2020 ~7 min

Research highlights immune molecule’s complex role in Huntington’s disease

Knocking out the immune cytokine IL-6 exacerbates symptoms in HD model mice, affects neural connection genes.

David Orenstein | Picower Institute for Learning and Memory • mit
June 8, 2020 ~4 min

Making tissue stretchable, compressible, and nearly indestructible

Chemical process called ELAST allows labeling probes to infuse more quickly, and makes samples tough enough for repeated handling.

David Orenstein | Picower Institute for Learning and Memory • mit
May 20, 2020 ~7 min

Scientists find a new way to reverse symptoms of Fragile X

Drug compound, tested in mice, could be effective in treating the leading heritable cause of intellectual disability and autism.

Anne Trafton | MIT News Office • mit
May 20, 2020 ~8 min


Study finds that aging neurons accumulate DNA damage

Reactivating an enzyme that promotes DNA repair can help to reverse age-related cognitive decline in mice.

Anne Trafton | MIT News Office • mit
May 18, 2020 ~5 min

Neuroscientists find memory cells that help us interpret new situations

Neurons that store abstract representations of past experiences are activated when a new, similar event takes place.

Anne Trafton | MIT News Office • mit
April 6, 2020 ~7 min

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