New computational tool predicts cell fates and genetic perturbations

The technique can help predict a cell’s path over time, such as what type of cell it will become.

Greta Friar | Whitehead Institute • mit
Feb. 3, 2022 ~9 min

Making RNA vaccines easier to swallow

A pill that releases RNA in the stomach could offer a new way to administer vaccines, or to deliver therapies for gastrointestinal disease.

Anne Trafton | MIT News Office • mit
Jan. 31, 2022 ~7 min


Speeding up directed evolution of molecules in the lab

Using a new robotic platform, researchers can simultaneously track hundreds of microbial populations as they evolve new proteins or other molecules.

Anne Trafton | MIT News Office • mit
Dec. 30, 2021 ~8 min

Measuring cancer cell state can reveal drug susceptibility

Study results also show that pancreatic tumor cells can be forced into a more susceptible state by changing their environment.

Anne Trafton | MIT News Office • mit
Dec. 9, 2021 ~8 min

Engineers devise a way to selectively turn on RNA therapies in human cells

A new RNA-based control switch could be used to trigger production of therapeutic proteins to treat cancer or other diseases.

Anne Trafton | MIT News Office • mit
Oct. 28, 2021 ~7 min

New programmable gene editing proteins found outside of CRISPR systems

Researchers find RNA-guided enzymes are more diverse and widespread than previously believed.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
Sept. 15, 2021 ~6 min

Scientists harness human protein to deliver molecular medicines to cells

Made of components found in the human body, the programmable system is a step toward safer, targeted delivery of gene editing and other molecular therapeutics.

Broad Institute • mit
Aug. 19, 2021 ~8 min

An on-off switch for gene editing

New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.

Eva Frederick | Whitehead Institute • mit
April 14, 2021 ~9 min


Basic cell health systems wear down in Huntington’s disease, analysis shows

A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis.

David Orenstein | Picower Institute for Learning and Memory • mit
Feb. 24, 2021 ~6 min

A high-resolution glimpse of gene expression in cells

Expanding tissue samples before sequencing allows researchers to pinpoint locations of RNA molecules.

Anne Trafton | MIT News Office • mit
Jan. 28, 2021 ~7 min

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