How worms move: Dopamine helps nematodes coordinate motor behaviors

To spy on worms for days on end, Picower Institute scientists invent a new open-source microscopy platform.

David Orenstein | Picower Institute for Learning and Memory • mit
June 30, 2020 ~8 min

Tags: neuroscience microscopy animals research school-of-science brain-and-cognitive-sciences national-science-foundation-nsf national-institutes-of-health-nih picower-institute

Like a treasure map, brain region emphasizes reward location

The lateral septum encodes spatial information with a special emphasis on where the reward lies.

David Orenstein | Picower Institute for Learning and Memory • mit
June 23, 2020 ~4 min

Tags: neuroscience biology memory learning research school-of-science brain-and-cognitive-sciences picower-institute

Study finds path for addressing Alzheimer’s blood-brain barrier impairment

MIT researchers pinpoint mechanism and demonstrate that drugs could help.

David Orenstein | Picower Institute for Learning and Memory • mit
June 15, 2020 ~7 min

Tags: stem-cells medicine neuroscience alzheimers tissue-engineering research drug-development school-of-science brain-and-cognitive-sciences picower-institute

Research highlights immune molecule’s complex role in Huntington’s disease

Knocking out the immune cytokine IL-6 exacerbates symptoms in HD model mice, affects neural connection genes.

David Orenstein | Picower Institute for Learning and Memory • mit
June 8, 2020 ~4 min

Tags: neuroscience immunology broad-institute disease research school-of-science brain-and-cognitive-sciences picower-institute

Making tissue stretchable, compressible, and nearly indestructible

Chemical process called ELAST allows labeling probes to infuse more quickly, and makes samples tough enough for repeated handling.

David Orenstein | Picower Institute for Learning and Memory • mit
May 20, 2020 ~7 min

Tags: neuroscience imaging microscopy tissue-engineering research school-of-engineering national-institutes-of-health-nih institute-for-medical-engineering-and-science-imes picower-institute chemical-engineering

Scientists find a new way to reverse symptoms of Fragile X

Drug compound, tested in mice, could be effective in treating the leading heritable cause of intellectual disability and autism.

Anne Trafton | MIT News Office • mit
May 20, 2020 ~8 min

Tags: medicine autism broad-institute research school-of-science brain-and-cognitive-sciences picower-institute

Study finds that aging neurons accumulate DNA damage

Reactivating an enzyme that promotes DNA repair can help to reverse age-related cognitive decline in mice.

Anne Trafton | MIT News Office • mit
May 18, 2020 ~5 min

Tags: neuroscience alzheimers aging research school-of-science brain-and-cognitive-sciences national-institutes-of-health-nih picower-institute

Neuroscientists find memory cells that help us interpret new situations

Neurons that store abstract representations of past experiences are activated when a new, similar event takes place.

Anne Trafton | MIT News Office • mit
April 6, 2020 ~7 min

Tags: neuroscience memory research school-of-science brain-and-cognitive-sciences picower-institute


With these neurons, extinguishing fear is its own reward

The same neurons responsible for encoding reward also form new memories to suppress fearful ones.

David Orenstein | Picower Institute • mit
Jan. 21, 2020 ~7 min

Tags: neuroscience mental-health anxiety biology memory learning research school-of-science brain-and-cognitive-sciences picower-institute

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