New technologies reveal cross-cutting breakdowns in Alzheimer’s disease

“Single-cell profiling” is helping neuroscientists see how disease affects major brain cell types and identify common, potentially targetable pathways.

David Orenstein | Picower Institute for Learning and Memory • mit
Jan. 18, 2023 ~6 min

Holding information in mind may mean storing it among synapses

Comparing models of working memory with real-world data, MIT researchers find information resides not in persistent neural activity, but in the pattern of its connections.

David Orenstein | Picower Institute for Learning and Memory • mit
Jan. 12, 2023 ~8 min


Small studies of 40-hertz sensory stimulation confirm safety, suggest Alzheimer’s benefits

MIT researchers report early-stage clinical study results of tests with noninvasive 40-hertz light and sound treatment.

David Orenstein | Picower Institute for Learning and Memory • mit
Dec. 13, 2022 ~9 min

Alzheimer’s risk gene undermines insulation of brain’s “wiring”

In people carrying APOE4, a key brain cell mismanages cholesterol needed to insulate neurons properly — another sign APOE4 contributes to disease by disrupting brain lipids.

David Orenstein | Picower Institute for Learning and Memory • mit
Nov. 22, 2022 ~8 min

Are Covid-19 “comas” signs of a protective hibernation state?

Scientists hypothesize that, as in a hibernating turtle, the brain under sedation and deprived of oxygen may assume a protective state.

David Orenstein | Picower Institute for Learning and Memory • mit
Nov. 18, 2022 ~5 min

Celebrating 20 years of discovery, Picower Institute looks ahead to continuing impact

At an exhibition marking two decades since a transformative gift from the Picower Foundation, current and alumni members described research at the forefront of neuroscience and beyond.

David Orenstein | Picower Institute for Learning and Memory • mit
Oct. 12, 2022 ~15 min

With fractured genomes, Alzheimer’s neurons call for help

Study indicates ailing neurons may instigate an inflammatory response from the brain’s microglia immune cells.

David Orenstein | Picower Institute for Learning and Memory • mit
Oct. 4, 2022 ~8 min

Providing new pathways for neuroscience research and education

Payton Dupuis finds new scientific interests and career opportunities through MIT summer research program in biology.

Leah Campbell | School of Science • mit
Sept. 29, 2022 ~8 min


Study reveals how environment and state are integrated to control behavior

A simple animal model shows how stimuli and states such as smells, stressors, and satiety converge in an olfactory neuron to guide food-seeking behavior.

David Orenstein | Picower Institute for Learning and Memory • mit
Sept. 15, 2022 ~8 min

How the brain focuses on what’s in mind

When holding information in mind, neural activity is more focused when and where there are bursts of gamma frequency rhythms.

David Orenstein | Picower Institute for Learning and Memory • mit
Sept. 13, 2022 ~7 min

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