Microscopy technique reveals hidden nanostructures in cells and tissues

Separating densely packed molecules before imaging allows them to become visible for the first time.

Anne Trafton | MIT News Office • mit
Aug. 29, 2022 ~8 min

When Alzheimer’s degrades cells that cross hemispheres, visual memory suffers

Research reveals cells that span brain hemispheres to coordinate activity in visual processing centers, shows Alzheimer’s degrades their structure and function.

David Orenstein | Picower Institute for Learning and Memory • mit
Aug. 24, 2022 ~7 min


When a task adds more steps, this brain circuit helps you notice

By tracking feedback during tasks, the anterior cingulate cortex notices when a new step has become necessary and signals the motor cortex to adjust.

David Orenstein | Picower Institute for Learning and Memory • mit
Aug. 18, 2022 ~8 min

How microglia contribute to Alzheimer’s disease

A breakdown of lipid metabolism in these brain cells promotes inflammation and interferes with neuron activity, a new study finds.

Anne Trafton | MIT News Office • mit
Aug. 4, 2022 ~7 min

Advanced imaging reveals mired migration of neurons in Rett syndrome lab models

Using organoids to model early development, researchers used an emerging microscopy technology to see that new neurons struggled to reach their developmental destination.

David Orenstein | Picower Institute for Learning and Memory • mit
Aug. 3, 2022 ~7 min

Sprint then stop? The brain is wired for the math to make it happen

To ensure a quick halt, brain circuit architecture avoids a slow process of integration in favor of quicker differentiation, study finds.

David Orenstein | Picower Institute for Learning and Memory • mit
July 28, 2022 ~6 min

New findings reveal how neurons build and maintain their capacity to communicate

Nerve cells regulate and routinely refresh the collection of calcium channels that enable them to send messages across circuit connections.

David Orenstein | Picower Institute for Learning and Memory • mit
July 21, 2022 ~8 min

Circuit that focuses attention brings in wide array of inputs

With a comprehensive map of the wiring, researchers can now discern what information flows into the circuit to enable a key brain function.

David Orenstein | Picower Institute for Learning and Memory • mit
May 6, 2022 ~5 min


A single memory is stored across many connected brain regions

Innovative brain-wide mapping study shows that an “engram,” the ensemble of neurons encoding a memory, is widely distributed and includes regions not previously realized.

David Orenstein | Picower Institute for Learning and Memory • mit
May 2, 2022 ~9 min

Neurons are fickle. Electric fields are more reliable for information.

Electric fields may represent information held in working memory, allowing the brain to overcome “representational drift,” or the inconsistent participation of individual neurons.

David Orenstein | Picower Institute for Learning and Memory • mit
April 4, 2022 ~7 min

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