Dramatic drops in ER visits likely led to uncounted deaths

A Beth Israel Deaconess Medical Center study showed dramatic drops in hospital visits for heart attacks and stroke, which likely led to uncounted deaths at home during the COVID crisis. Perhaps more troubling is the potential for long-term damage to decades’ work to catch conditions in their earliest, most treatable stages.

Alvin Powell • harvard
May 22, 2020 ~12 min

Tags: health-medicine alvin-powell beth-israel-deaconess-medical-center cancer coronavirus covid-19 dhruv-kazi emergency-room harvard-medical-school heart-attack stroke

A connection between ancestry and the molecular makeup of cancer

A new study takes the most comprehensive look to date at the connection between the ancestry and the molecular makeup of cancer.

Rob Levy • harvard
May 11, 2020 ~7 min

Tags: health-medicine ancestry basic-research broad-institute cancer human-genome-project nci-cancer-genome-analysis-network tumors

Scientists produce a reference map of human protein interactions

Scientists produce a reference map of human protein interactions, releasing data helpful for understanding diseases including cancer and infectious diseases such as COVID-19.

Jovana Drinjakovic • harvard
April 8, 2020 ~7 min

Tags:  science-technology  basic-research  cancer  center-for-cancer-systems-biology  covid-19  dana-farber-cancer-institute  genes  human-genome-project  human-reference-interactome  infectious-diseases  interactome

In clinical study, blood test can detect range of cancers

In a study involving thousands of participants, a new blood test detected more than 50 types of cancer as well as their location within the body with a high degree of accuracy.

Harvard Gazette • harvard
March 31, 2020 ~4 min

Tags:  health-medicine  annals-of-oncology  basic-research  cancer  dna  grail  harvard-medical-school  pathfinder

Removing the constraining requirements at gene editing site

Investigators at Massachusetts General Hospital have modified the gene editing system, making it possible to potentially target any location across the entire human genome.

Harvard Gazette • harvard
March 26, 2020 ~3 min

Tags:  science-technology  basic-research  benjamin-p-kleinstiver  blindness  cancer  cas9  center-for-genomic-medicine  crispr  gene-editing  mgh

Personalized blood biopsies may provide signal of cancer recurrence

Researchers have designed personalized blood biopsies that offer the potential of an early warning signal of breast cancer recurrence.

Karen Zusi • harvard
March 13, 2020 ~8 min

Tags:  science-technology  basic-research  blood-biopsies  breast-cancer  broad-institute-of-mit-and-harvard  dana-farber-cancer-institute  gerstner-center-for-cancer-diagnostics  tumor-mutations

NIH-funded i3 Center formed to advance cancer immunotherapy

Harvard’s Wyss Institute will collaborate with other institutions to form the i3 Center where cancer immunologists and biological engineers will develop new biomaterials-based approaches to enable anti-cancer immune-therapies for therapy-resistant cancers.

Benjamin Boettner • harvard
March 6, 2020 ~9 min

Tags:  science-technology  basic-research  engineering  harvard-john-a-paulson-school-of-engineering-and-applied-sciences-dana-farber-cancer-institute  harvards-department-of-stem-cell-and-regenerative-biology  i3-center  immune-therapies  immuno-engineering-to-improve-immunotherapy-i3-center  therapy-resistant-cancers  wyss-institute-of-biologically-inspired-engineering-at-harvard-university

U.S. life expectancy goes up as cancer deaths go down

A decline in cancer mortality was a prominent feature of recent good news about U.S. life expectancy. The Gazette spoke with the director of the Chan School’s Zhu Family Center for Global Cancer Prevention to understand why.

Alvin Powell • harvard
Feb. 21, 2020 ~14 min

Tags:  health-medicine  alvin-powell  basic-research  breast-cancer  cancer  cervical-cancer  disparities  harvard-th-chan-school-of-public-health  life-expectancy  melanoma  national-center-for-health-statistic  prostate-cancer  timothy-rebbeck  zhu-family-center-for-global-cancer-prevention

New class of enzymes could lead to bespoke diets, therapeutics

Professor Emily Balskus and her team have identified an entirely new class of enzymes that degrade chemicals essential for neurological health, but also help digest foods like nuts, berries, and tea, releasing nutrients that may impact human health.

Caitlin McDermott-Murphy • harvard
Feb. 18, 2020 ~6 min

Tags:  science-technology  bacteria  basic-research  berries  bespoke-diets  caitlin-mcdermott-murphy  cancer  chemistry  chemistry-and-chemical-biology  chocolate  coffee  diet  dopamine  emily-balskus  enzymes  gut  l-dopa  microbes  microbiology  microbiome  nutrition  nuts  parkinsons-disease  science  vayu-maini-rekdal

Novel drug targets tumor growth in advanced kidney cancer

Harvard researchers at Dana-Farber Cancer Institute have developed a novel targeted drug that shows promise in advanced kidney cancer by interfering with the abnormal blood vessel formation that fuels tumor growth.

Richard Saltus • harvard
Feb. 12, 2020 ~4 min

Tags:  health-medicine  basic-research  clear-cell-renal-cell-carcinoma  dana-farber-cancer-institute  hypoxia-inducible-factor  kidney-cancer  metastatic-disease  mk-6482  nobel-prize  phase-iii  toni-choueiri  tumors  william-g-kaelin-jr

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