RNA molecules are masters of their own destiny

Research suggests the products of transcription — RNA molecules — regulate their own production through a feedback loop.

Eva Frederick | Whitehead Institute • mit
Jan. 5, 2021 ~8 min

physics chemistry genetics biology rna research drug-development school-of-engineering school-of-science whitehead-institute chemical-engineering

3 Questions: Phillip Sharp on the discoveries that enabled RNA vaccines for Covid-19

Curiosity-driven basic science in the 1970s laid the groundwork for today’s leading vaccines against the novel coronavirus.

School of Science • mit
Dec. 11, 2020 ~9 min

genetics covid-19 biology pandemic rna vaccines history-of-science research school-of-science faculty 3-questions koch-institute

Regulating the regulators

Tiny microRNAs help destroy unwanted messenger RNAs in cells. New research finds how the body keeps them in check.

Eva Frederick | Whitehead Institute • mit
Nov. 24, 2020 ~6 min

genetics crispr biology rna research whitehead-institute

Silencing gene expression to cure complex diseases

Immuneering uses bioinformatics to develop new medicines while also helping large pharmaceutical companies improve their treatments.

Zach Winn | MIT News Office • mit
Oct. 26, 2020 ~9 min

health medicine genetics cancer startups biology rna alzheimers data disease research drug-development school-of-engineering innovation-and-entrepreneurship-ie alumniae biological-engineering

To make mini-organs grow faster, give them a squeeze

Study finds that compressing cells, and crowding their contents, can coax them to grow and divide.

Jennifer Chu | MIT News Office • mit
Oct. 13, 2020 ~7 min

genetics cancer biology research cells mechanical-engineering school-of-engineering biological-engineering

Neuroscientists discover a molecular mechanism that allows memories to form

Modifications to chromosomes in “engram” neurons control the encoding and retrieval of memories.

Anne Trafton | MIT News Office • mit
Oct. 5, 2020 ~7 min

dna genetics neuroscience memory research school-of-science brain-and-cognitive-sciences picower-institute

Nanoparticles can turn off genes in bone marrow cells

Using these new particles, researchers could develop treatments for heart disease and other conditions.

Anne Trafton | MIT News Office • mit
Oct. 5, 2020 ~8 min

genetics rna research school-of-engineering nanoscience-and-nanotechnology koch-institute institute-for-medical-engineering-and-science-imes chemical-engeering

New gene regulation model provides insight into brain development

A well-known protein family binds to many more RNA sequences than previously thought in order to help neurons grow.

Raleigh McElvery | Department of Biology • mit
Sept. 8, 2020 ~7 min

genetics neuroscience development biology data research school-of-science computer-modeling

Scientists discover new rules about “runaway” transcription

Findings related to bacterial gene expression overturn fundamental assumptions about basic biological pathways.

Raleigh McElvery | Department of Biology • mit
Sept. 2, 2020 ~7 min

dna physics genetics bacteria biology rna research school-of-science

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