“Single-cell profiling” is helping neuroscientists see how disease affects major brain cell types and identify common, potentially targetable pathways.

Prochlorococcus, the world’s most abundant photosynthetic organism, reveals a gene-transfer mechanism that may be key to its abundance and diversity.

Known as PASTE, the technique holds potential for treating a variety of diseases caused by faulty genes.

In people carrying APOE4, a key brain cell mismanages cholesterol needed to insulate neurons properly — another sign APOE4 contributes to disease by disrupting brain lipids.

Researchers harness new pooled, image-based screening method to probe the functions of over 5,000 essential genes in human cells.

By analyzing enzyme activity at the organism, tissue, and cellular scales, new sensors could provide new tools to clinicians and cancer researchers.

Study finds the protein MTCH2 is responsible for shuttling various other proteins into the membrane of mitochondria. The finding could have implications for cancer treatments and MTCH2-linked conditions.

A machine-learning method finds patterns of health decline in ALS, informing future clinical trial designs and mechanism discovery. The technique also extends to Alzheimer’s and Parkinson’s.

A computational analysis reveals that many repetitive sequences are shared across proteins and are similar in species from bacteria to humans.

A new model that maps developmental pathways to tumor cells may unlock the identity of cancers of unknown primary.